Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves
dysregulation of many cellular and molecular processes. It is notoriously difficult to develop …

Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …

Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

The hippocampus is critical for learning and memory, relying in part on pattern separation
processes supported by the dentate gyrus (DG) to prevent interference from overlap** …

Many cognitive abilities decline with age even in the absence of detectable pathology.
Recent evidence indicates that age-related neural dedifferentiation, operationalized in terms …

The discovery of neuronal systems dedicated to computing spatial information, composed of
functionally distinct cell types such as place and grid cells, combined with an extensive body …

The hippocampus has a pivotal role in learning and in the formation and consolidation of
memory and is critically involved in the regulation of emotion, fear, anxiety, and stress …

Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness
and potential impact on cognition but also to its localized vertical integration of different …

The ability to discriminate among similar experiences is a crucial feature of episodic
memory. This ability has long been hypothesized to require the hippocampus, and …

Adult-born granule cells (abGCs) have been implicated in cognition and mood; however, it
remains unknown how these cells behave in vivo. Here, we have used two-photon calcium …