Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

This review summarizes recent evidence concerning molecular changes in the commonest
type of lymphoma, diffuse large-B-cell lymphoma. Detailed studies have revealed three …

The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) remains
the least curable form of this malignancy despite recent advances in therapy. Constitutive …

A20 (also known as TNFAIP3) is a potent anti-inflammatory signalling molecule that restricts
multiple intracellular signalling cascades. Recent studies in three general areas have …

Although known for many years as a nuclear factor (NF)-κB inhibitory and antiapoptotic
signaling protein, A20 has recently attracted much attention because of its ubiquitin …

Deubiquitinases (DUBs) have fundamental roles in the ubiquitin system through their ability
to specifically deconjugate ubiquitin from targeted proteins. The human genome encodes at …

Primary Sjögren's syndrome (pSS) is a prototypic autoimmune disorder, management of
which has long suffered from a lack of knowledge of the underlying pathophysiological …

Extranodal marginal zone (MZ) B-cell lymphomas of the mucosa-associated lymphoid tissue
(MALT) arise from lymphoid populations that are induced by chronic inflammation in …

The ubiquitin proteasome system (UPS) is the main system for controlled protein
degradation and a key regulator of fundamental cellular processes. The dependency of …

Nuclear factor (NF)-κB has an important role in immunity and inappropriate NF-κB activity
has been linked with many autoimmune and inflammatory diseases. Multiple mechanisms …