Temperature is one of the main environmental cues affecting plant growth and development,
and plants have evolved multiple mechanisms to sense and acclimate to high temperature …

Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi
and Leishmania, are the only known organisms that do not regulate the transcription of …

Temperature is a major environmental cue affecting plant growth and development. Plants
often experience higher temperatures in the context of a 24 h day–night cycle, with …

Leishmania spp. are protozoan parasites that have two principal life cycle stages: the motile
promastigote forms that live in the alimentary tract of the sandfly and the amastigote forms …

In most organisms, the heat-shock response involves increased heat-shock gene
transcription. In Kinetoplastid protists, however, virtually all control of gene expression is …

RNA molecules have the capacity to form a multitude of distinct secondary and tertiary
structures, but only the most energetically favorable conformations are adopted at any given …

Regulation of gene expression in Kinetoplastids relies mainly on post-transcriptional
mechanisms. Recent high-throughput analyses, combined with mathematical modelling …

Regulatory RNA elements fulfill functions such as translational regulation, control of
transcript levels, and regulation of viral genome replication. Trans-acting factors (ie, RNA …

The ability of Leishmania to survive in their insect or mammalian host is dependent upon an
ability to sense and adapt to changes in the microenvironment. However, little is known …

Neglected parasitic diseases affect millions of people worldwide, resulting in high morbidity
and mortality. Among other parasitic diseases, leishmaniasis remains an important public …