Two-component systems reprogramme diverse aspects of microbial physiology in response
to environmental cues. Canonical systems are composed of a transmembrane sensor …

Histidine kinases (HKs) are major players in bacterial signaling. There has been an
explosion of new HK crystal structures in the last 5 years. We globally analyze the structures …

Phytochromes are red-light photoreceptors discovered in plants with homologs in bacteria
and fungi that regulate a variety of physiological responses. They display a reversible …

Perceiving environmental and internal information and reacting in adaptive ways are
essential attributes of living organisms. Two-component systems are relevant protein …

Two-component regulatory systems represent the major paradigm for signal transduction in
prokaryotes. The simplest systems are composed of a sensor kinase and a response …

Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few
treatment options being available. New therapeutics are urgently needed to relieve the …

The norepinephrine pathway is believed to modulate behavioral and physiological
processes, such as mood, overall arousal, and attention. Furthermore, abnormalities in the …

Critical assessment of structure prediction (CASP) conducts community experiments to
determine the state of the art in computing protein structure from amino acid sequence. The …

Adaptation to environments with constant fluctuations imposes challenges that are only
overcome with sophisticated strategies that allow bacteria to perceive environmental …

Orthogonal tools for controlling protein function by post-translational modifications open up
new possibilities for protein circuit engineering in synthetic biology. Phosphoregulation is a …