Snake venomics: fundamentals, recent updates, and a look to the next decade

CH Tan - Toxins, 2022 - mdpi.com
Venomic research, powered by techniques adapted from proteomics, transcriptomics, and
genomics, seeks to unravel the diversity and complexity of venom through which knowledge …

Never, Ever make an enemy… out of an anemone: Transcriptomic comparison of clownfish hosting sea anemone venoms

A Delgado, C Benedict, J Macrander, M Daly - Marine Drugs, 2022 - mdpi.com
Sea anemones are predatory marine invertebrates and have diverse venom arsenals.
Venom is integral to their biology, and is used in competition, defense, and feeding. Three …

Phylogenetically diverse diets favor more complex venoms in North American pitvipers

ML Holding, JL Strickland… - Proceedings of the …, 2021 - National Acad Sciences
The role of natural selection in the evolution of trait complexity can be characterized by
testing hypothesized links between complex forms and their functions across species …

The Tiger Rattlesnake genome reveals a complex genotype underlying a simple venom phenotype

MJ Margres, RM Rautsaw… - Proceedings of the …, 2021 - National Acad Sciences
Variation in gene regulation is ubiquitous, yet identifying the mechanisms producing such
variation, especially for complex traits, is challenging. Snake venoms provide a model …

Modern venomics—Current insights, novel methods, and future perspectives in biological and applied animal venom research

BM von Reumont, G Anderluh, A Antunes… - …, 2022 - academic.oup.com
Venoms have evolved> 100 times in all major animal groups, and their components, known
as toxins, have been fine-tuned over millions of years into highly effective biochemical …

Size Matters: An Evaluation of the Molecular Basis of Ontogenetic Modifications in the Composition of Bothrops jararacussu Snake Venom

LA Freitas-de-Sousa, PG Nachtigall, JA Portes-Junior… - Toxins, 2020 - mdpi.com
Ontogenetic changes in venom composition have been described in Bothrops snakes, but
only a few studies have attempted to identify the targeted paralogues or the molecular …

[PDF][PDF] Independent Recruitment of Different Types of Phospholipases A2 to the Venoms of Caenophidian Snakes: The Rise of PLA2-IIE within Pseudoboini …

JD Bayona-Serrano, FG Grazziotin… - Molecular Biology …, 2023 - academic.oup.com
Snake venoms harbor a wide and diverse array of enzymatic and nonenzymatic toxic
components, allowing them to exert myriad effects on their prey. However, they appear to …

Comparative venom-gland transcriptomics and venom proteomics of four Sidewinder Rattlesnake (Crotalus cerastes) lineages reveal little differential expression …

EP Hofmann, RM Rautsaw, JL Strickland… - Scientific Reports, 2018 - nature.com
Abstract Changes in gene expression can rapidly influence adaptive traits in the early
stages of lineage diversification. Venom is an adaptive trait comprised of numerous toxins …

Longest protein, longest transcript or most expression, for accurate gene reconstruction of transcriptomes?

DG Gilbert - BioRxiv, 2019 - biorxiv.org
Methods of transcript assembly and reduction filters are compared for recovery of reference
gene sets of human, pig and plant, including longest coding sequence with EvidentialGene …

ToxCodAn-Genome: an automated pipeline for toxin-gene annotation in genome assembly of venomous lineages

PG Nachtigall, AM Durham, DR Rokyta… - …, 2024 - academic.oup.com
Background The rapid development of sequencing technologies resulted in a wide
expansion of genomics studies using venomous lineages. This facilitated research focusing …