Maintenance of genomic integrity is critical for the perpetuation of all forms of life including
humans. Living organisms are constantly exposed to stress from internal metabolic …

Abstract α-Synuclein is a hallmark amyloidogenic protein component of the Lewy bodies
(LBs) present in dopaminergic neurons affected by Parkinson's disease (PD). Despite an …

Deficiency of DNA repair pathways drives the development of colorectal cancer. However,
the role of the base excision repair (BER) pathway in colorectal cancer initiation remains …

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm accounting for∼ 15% of
all leukemia. Progress of the disease from an indolent chronic phase to the more aggressive …

Background/Aims: Over 99% of mouse and human ovarian follicles will undergo specialized
cell death including atresia and apoptosis. Reduction of apoptosis may help reduce infertility …

Human genome stability requires efficient repair of oxidized bases, which is initiated via
damage recognition and excision by NEIL1 and other base excision repair (BER) pathway …

Pre-mRNA encoding human NEIL1 undergoes editing by adenosine deaminase ADAR1
that converts a single adenosine to inosine, and this conversion results in an amino acid …

The maintenance of human mitochondrial DNA (mtDNA) is critical for proper cellular function
as damage to mtDNA, if left unrepaired, can lead to a diverse array of pathologies. Of the …

Cancer is a multi-step process during which cells acquire mutations that eventually lead to
uncontrolled cell growth and division and evasion of programmed cell death. The …

Among several reversible epigenetic changes occurring during transcriptional activation,
only demethylation of histones and cytosine-phosphate-guanines (CpGs) in gene promoters …