ERK: a key player in the pathophysiology of cardiac hypertrophy
Cardiac hypertrophy is an adaptive and compensatory mechanism preserving cardiac
output during detrimental stimuli. Nevertheless, long-term stimuli incite chronic hypertrophy …
output during detrimental stimuli. Nevertheless, long-term stimuli incite chronic hypertrophy …
The biology of IQGAP proteins: beyond the cytoskeleton
IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the
formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and …
formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and …
IQGAP1 and its binding proteins control diverse biological functions
IQGAP proteins have been identified in a wide spectrum of organisms, ranging from yeast to
humans. The most extensively studied family member is the ubiquitously expressed scaffold …
humans. The most extensively studied family member is the ubiquitously expressed scaffold …
IQGAPs choreograph cellular signaling from the membrane to the nucleus
Since its discovery in 1994, recognized cellular functions for the scaffold protein IQGAP1
have expanded immensely. Over 100 unique IQGAP1-interacting proteins have been …
have expanded immensely. Over 100 unique IQGAP1-interacting proteins have been …
The long noncoding RNA CARDINAL attenuates cardiac hypertrophy by modulating protein translation
X He, T Yang, YW Lu, G Wu, G Dai, Q Ma… - The Journal of clinical …, 2024 - jci.org
One of the features of pathological cardiac hypertrophy is enhanced translation and protein
synthesis. Translational inhibition has been shown to be an effective means of treating …
synthesis. Translational inhibition has been shown to be an effective means of treating …
Agonist-stimulated phosphatidylinositol-3, 4, 5-trisphosphate generation by scaffolded phosphoinositide kinases
Generation of the lipid messenger phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns (3, 4, 5)
P3) is crucial for development, cell growth and survival, and motility, and it becomes …
P3) is crucial for development, cell growth and survival, and motility, and it becomes …
The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling
The scaffold protein IQGAP1 assembles multiprotein signaling complexes to influence
biological functions. Cell surface receptors, particularly receptor tyrosine kinases and G …
biological functions. Cell surface receptors, particularly receptor tyrosine kinases and G …
MYL9 expressed in cancer-associated fibroblasts regulate the immune microenvironment of colorectal cancer and promotes tumor progression in an autocrine …
S Deng, D Cheng, J Wang, J Gu, Y Xue, Z Jiang… - Journal of Experimental …, 2023 - Springer
Background The tumor microenvironment (TME) is an important factor that regulates the
progression of colorectal cancer (CRC). Cancer-associated fibroblasts (CAFs) are the main …
progression of colorectal cancer (CRC). Cancer-associated fibroblasts (CAFs) are the main …
IQGAP1: insights into the function of a molecular puppeteer
The intracellular spatiotemporal organization of signaling events is critical for normal cellular
function. In response to environmental stimuli, cells utilize highly organized signaling …
function. In response to environmental stimuli, cells utilize highly organized signaling …
Mitogen-activated protein (MAP) kinase scaffolding proteins: a recount
M Meister, A Tomasovic, A Banning… - International journal of …, 2013 - mdpi.com
The mitogen-activated protein kinase (MAPK) pathway is the canonical signaling pathway
for many receptor tyrosine kinases, such as the Epidermal Growth Factor Receptor …
for many receptor tyrosine kinases, such as the Epidermal Growth Factor Receptor …