This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

Neuronal apoptosis sculpts the develo** brain and has a potentially important role in
neurodegenerative diseases. The principal molecular components of the apoptosis …

The term spreading depolarization describes a wave in the gray matter of the central
nervous system characterized by swelling of neurons, distortion of dendritic spines, a large …

Lymphocyte recruitment and activation have been implicated in the progression of cerebral
ischemia-reperfusion (I/R) injury, but the roles of specific lymphocyte subpopulations and …

A form of cell death called apoptosis is a prominent feature in a broad spectrum of
neurodegenerative diseases, ranging from stroke to Huntington's disease. Hypoxia, toxic …

Cerebral ischemia (stroke) triggers a complex series of biochemical and molecular
mechanisms that impairs the neurologic functions through breakdown of cellular integrity …

Antibody-based anticancer agents are promising chemotherapeutic agents. Among these
agents, Herceptin (trastuzumab), a humanized anti-human epidermal growth factor receptor …

Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal
transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable …

Neuronal apoptosis was observed in the rat dentate gyrus in two experimental models of
human limbic epilepsy. Five hours after one hippocampal kindling stimulation, a marked …

The interleukin 1β converting enzyme (ICE) family plays a pivotal role in programmed cell
death and has been implicated in stroke and neurodegenerative diseases. During …