Targeted drug delivery—from magic bullet to nanomedicine: principles, challenges, and future perspectives

A Tewabe, A Abate, M Tamrie, A Seyfu… - Journal of …, 2021 - Taylor & Francis
Nanomedicine is an advanced version of Paul Ehrlich's “magic bullet” concept. Targeted
drug delivery is a system of specifying the drug moiety directly into its targeted body area …

[HTML][HTML] Implementation of quality by design (QbD) for development of bilayer tablets

J Simão, SA Chaudhary, AJ Ribeiro - European Journal of Pharmaceutical …, 2023 - Elsevier
Bilayer tablets offer various drug release profiles for individual drugs incorporated in each
layer of a bilayer tablet, which is rarely achievable by conventional tablets. These tablets …

Fabrication of bilayer tablets using hot melt extrusion-based dual-nozzle fused deposition modeling 3D printing

P Zhang, P Xu, S Chung, S Bandari… - International Journal of …, 2022 - Elsevier
The objective of this study was to fabricate bilayer tablets using hot-melt extrusion (HME)-
based dual-nozzle fused deposition modeling (FDM) three-dimensional (3D) printing …

Optimization of bilayer tablet manufacturing process for fixed dose combination of sustained release high-dose drug and immediate release low-dose drug based on …

DH Won, H Park, ES Ha, HH Kim, SW Jang… - International Journal of …, 2021 - Elsevier
A fixed dose combination (FDC) bilayer tablet, consisting of high-dose metformin HCl in a
sustained release layer and low-dose evogliptin tartrate in an immediate release layer, was …

[HTML][HTML] Potential of pullulan-based polymeric nanoparticles for improving drug physicochemical properties and effectiveness

N Thomas, LE Puluhulawa, FR Cindana Mo'o… - Polymers, 2024 - mdpi.com
Pullulan, a natural polysaccharide with unique biocompatibility and biodegradability, has
gained prominence in nanomedicine. Its application in nanoparticle drug delivery systems …

Further enhancement of the sustained-release properties and stability of direct compression gel matrix bilayer tablets by controlling the particle size of HPMC and drug …

T Liu, J Wang, Y Feng, H Wang, Y Xu, T Yin, Y Zhang… - Powder Technology, 2024 - Elsevier
Abstract The Theophylline and Salbutamol Bilayer Sustained-release Tablets (Yi ** Qing®),
prepared via wet granulation, discolor during long-term storage, and the process is less …

Versatile functionalization of pectic conjugate: From design to biomedical applications

J Chen, MS Mei, Y Xu, S Shi, S Wang, H Wang - Carbohydrate Polymers, 2023 - Elsevier
Pectin exists extensively in nature and has attracted much attention in biological
applications for its unique chemical and physical characteristics. Functionalized pectin …

Biphasic drug release from rolled-up gelatin capsules with a cylindrical cavity

J Mzoughi, T Vandamme, V Luchnikov - Pharmaceutics, 2021 - mdpi.com
Biphasic drug delivery systems are used for quick release of a specific amount of drug for
immediate amelioration of a patient's state, followed by sustained release, to avoid repeated …

Core-shell tablets designed for modified and sequential release of ibuprofen and rabeprazole

B Khan, HI Choi, JS Ryu, HY Noh, FA Shah… - International Journal of …, 2024 - Elsevier
In this study, core–shell tablets comprising an ibuprofen (IBU) enteric-coated core for
modified release and a rabeprazole (RAB) shell for immediate release were developed …

NSAID solubilisation promotes morphological transitions in Triton X-114 surfactant micelles

H Ishkhanyan, RM Ziolek, DJ Barlow… - Journal of Molecular …, 2022 - Elsevier
The structural properties of micelles formed by the non-ionic surfactant, Triton X-114 (TX-
114), were investigated using all-atom molecular dynamics (MD) simulations. Additionally …