Abstract The Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK)
were developed to address widespread deficiencies in the reporting of such studies. The …

HER2 (human epidermal growth factor receptor 2) receptor is a membrane tyrosine kinase
and when activated affects cell proliferation and survival. The HER2 oncogene is located on …

Abstract Background The Reporting Recommendations for Tumor Marker Prognostic
Studies (REMARK) checklist consists of 20 items to report for published tumor marker …

Engineered nanoparticles have been used to provide diagnostic 1, 2, 3, therapeutic 4, 5 and
prognostic information 6, 7 about the status of disease. Nanoparticles developed for these …

Many genes and signalling pathways controlling cell proliferation, death and differentiation,
as well as genomic integrity, are involved in cancer development. New techniques, such as …

Learning Objectives Contrast the current strengths and limitations of the three main slide-
based techniques (IHC, FISH, and CISH) currently in clinical use for testing breast cancer …

The HER-2/neu oncogene encodes a transmembrane tyrosine kinase receptor with
extensive homology to the epidermal growth factor receptor. HER-2/neu has been widely …

Abstract Background: Updated National Academy of Clinical Biochemistry (NACB)
Laboratory Medicine Practice Guidelines for the use of tumor markers in the clinic have been …

To analyze HER2 amplification in a large cohort of diagnostic breast cancer specimens,
fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) were performed …

Abstract Learning Objectives After completing this course, the reader will be able to: Define
the historical background and biological basis of the discovery of the HER-2/neu gene and …