[HTML][HTML] Noninvasive evaluation of nonalcoholic fatty liver disease: Current evidence and practice

JH Zhou, JJ Cai, ZG She, HL Li - World journal of gastroenterology, 2019 - ncbi.nlm.nih.gov
With the increasing number of individuals with diabetes and obesity, nonalcoholic fatty liver
disease (NAFLD) is becoming increasingly prevalent, affecting one-quarter of adults …

[HTML][HTML] Metaflammation in glucolipid metabolic disorders: Pathogenesis and treatment

P **ong, F Zhang, F Liu, J Zhao, X Huang, D Luo… - Biomedicine & …, 2023 - Elsevier
The public health issue of glucolipid metabolic disorders (GLMD) has grown significantly,
posing a grave threat to human wellness. Its prevalence is rising yearly and tends to affect …

Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression

Q Zhang, X Yang, J Wu, S Ye, J Gong, WM Cheng… - Cell discovery, 2023 - nature.com
Metabolic reprogramming is a hallmark of cancer. However, it is not well known how
metabolism affects cancer progression. We identified that metabolic enzyme acyl-CoA …

Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK

C Ge, J Tan, X Dai, Q Kuang, S Zhong, L Lai… - Nature …, 2022 - nature.com
Nonalcoholic steatohepatitis (NASH), a common clinical disease, is becoming a leading
cause of hepatocellular carcinoma (HCC). Dual specificity phosphatase 22 (DUSP22, also …

Myeloid-derived growth factor alleviates non-alcoholic fatty liver disease alleviates in a manner involving IKKβ/NF-κB signaling

Y Ding, X Xu, B Meng, L Wang, B Zhu, B Guo… - Cell Death & …, 2023 - nature.com
Whether bone marrow modulates systemic metabolism remains unknown. Our recent study
suggested that myeloid-derived growth factor (MYDGF) improves insulin resistance. Here …

Liver fibrosis and MAFLD: from molecular aspects to novel pharmacological strategies

W Qu, T Ma, J Cai, X Zhang, P Zhang, Z She… - Frontiers in …, 2021 - frontiersin.org
Metabolic-associated fatty liver disease (MAFLD) is a new disease definition, and this
nomenclature MAFLD was proposed to renovate its former name, non-alcoholic fatty liver …

TNFAIP3 interacting protein 3 overexpression suppresses nonalcoholic steatohepatitis by blocking TAK1 activation

D Liu, P Zhang, J Zhou, R Liao, Y Che, MM Gao, J Sun… - Cell Metabolism, 2020 - cell.com
Nonalcoholic steatohepatitis (NASH) is an unmet clinical challenge due to the rapid
increase in its occurrence but the lack of approved drugs to treat it. Further unraveling of the …

Impact of conventional and atypical MAPKs on the development of metabolic diseases

T Kassouf, G Sumara - Biomolecules, 2020 - mdpi.com
The family of mitogen-activated protein kinases (MAPKs) consists of fourteen members and
has been implicated in regulation of virtually all cellular processes. MAPKs are divided into …

Role of innate immune signaling in non-alcoholic fatty liver disease

J Cai, XJ Zhang, H Li - Trends in Endocrinology & Metabolism, 2018 - cell.com
Non-alcoholic fatty liver disease (NAFLD) has become the most epidemic liver disease
worldwide owing to rapid changes in lifestyle over the past few decades. This chronic …

[HTML][HTML] Stress kinases in the development of liver steatosis and hepatocellular carcinoma

B Cicuéndez, I Ruiz-Garrido, A Mora, G Sabio - Molecular Metabolism, 2021 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is an important component of metabolic syndrome
and one the most prevalent liver diseases worldwide. This disorder is closely linked to …