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A hypothesis for pathobiology and treatment of COVID‐19: the centrality of ACE1/ACE2 imbalance
Angiotensin Converting Enzyme2 is the cell surface binding site for the coronavirus SARS‐
CoV‐2, which causes COVID‐19. We propose that an imbalance in the action of ACE1‐and …
CoV‐2, which causes COVID‐19. We propose that an imbalance in the action of ACE1‐and …
Targeting oxidative stress as a therapeutic approach for idiopathic pulmonary fibrosis
C Estornut, J Milara, MA Bayarri, N Belhadj… - Frontiers in …, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by an
abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis …
abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis …
Anti-SARS-CoV-2 activities of tanshinone IIA, carnosic acid, rosmarinic acid, salvianolic acid, baicalein, and glycyrrhetinic acid between computational and in vitro …
Six compounds namely, tanshinone IIA (1), carnosic acid (2), rosmarinic acid (3), salvianolic
acid B (4), baicalein (5), and glycyrrhetinic acid (6) were screened for their anti-SARS-CoV-2 …
acid B (4), baicalein (5), and glycyrrhetinic acid (6) were screened for their anti-SARS-CoV-2 …
[HTML][HTML] Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: Rationale and therapeutic potential
Y Zhang, P Lu, H Qin, Y Zhang, X Sun, X Song… - Biomedicine & …, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive pulmonary interstitial inflammatory
disease of unknown etiology, and is also a sequela in severe patients with the Coronavirus …
disease of unknown etiology, and is also a sequela in severe patients with the Coronavirus …
Traditional Chinese medicine for pulmonary fibrosis therapy: Progress and future prospects
LC Li, LD Kan - Journal of ethnopharmacology, 2017 - Elsevier
Ethnopharmacological relevance Pulmonary fibrosis (PF) is a chronic, debilitating and often
lethal lung disorder. Despite the molecular mechanisms of PF are gradually clear with …
lethal lung disorder. Despite the molecular mechanisms of PF are gradually clear with …
Tanshinone IIA attenuates silica-induced pulmonary fibrosis via Nrf2-mediated inhibition of EMT and TGF-β1/Smad signaling
F Feng, P Cheng, S Xu, N Li, H Wang, Y Zhang… - Chemico-Biological …, 2020 - Elsevier
Silicosis is an occupational pulmonary fibrosis that is caused by inhalation of silica (SiO 2),
and there are no effective drugs to treat this disease. Tanshinone IIA (Tan IIA), a natural …
and there are no effective drugs to treat this disease. Tanshinone IIA (Tan IIA), a natural …
[HTML][HTML] Salvia miltiorrhiza Bunge as a Potential Natural Compound against COVID-19
SJL Petitjean, M Lecocq, C Lelong, R Denis, S Defrère… - Cells, 2022 - mdpi.com
Salvia miltiorrhiza Bunge, commonly called danshen, is widely used in traditional Chinese
medicine for its cardiovascular and neuroprotective effects, which include antioxidative, anti …
medicine for its cardiovascular and neuroprotective effects, which include antioxidative, anti …
[HTML][HTML] A comprehensive review of tanshinone IIA and its derivatives in fibrosis treatment
Z Bi, Y Wang, W Zhang - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Abstract Tanshinone IIA (Tan IIA) is the most abundant lipid-soluble component in Salvia
miltiorrhiza. Both Tan IIA and its derivatives including Sodium tanshinone IIA sulfonate (STS) …
miltiorrhiza. Both Tan IIA and its derivatives including Sodium tanshinone IIA sulfonate (STS) …
A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor
The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …
prompted scientists to address an urgent need for defining mechanisms of disease …
Salvianolic acid B and sodium tanshinone II A sulfonate prevent pulmonary fibrosis through anti-inflammatory and anti-fibrotic process
L Jiang, J Wang, J Ju, J Dai - European journal of pharmacology, 2020 - Elsevier
Pulmonary fibrosis (PF) is an interstitial lung disease characterized by interstitial
inflammation and fibrosis. Salvianolic acid B (SAB) and sodium tanshinone IIA sulfonate …
inflammation and fibrosis. Salvianolic acid B (SAB) and sodium tanshinone IIA sulfonate …