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Gene duplication as a mechanism of genomic adaptation to a changing environment
FA Kondrashov - Proceedings of the Royal Society B …, 2012 - royalsocietypublishing.org
A subject of extensive study in evolutionary theory has been the issue of how neutral,
redundant copies can be maintained in the genome for long periods of time. Concurrently …
redundant copies can be maintained in the genome for long periods of time. Concurrently …
Venomics: integrative venom proteomics and beyond
JJ Calvete - Biochemical Journal, 2017 - portlandpress.com
Venoms are integrated phenotypes that evolved independently in, and are used for
predatory and defensive purposes by, a wide phylogenetic range of organisms. The same …
predatory and defensive purposes by, a wide phylogenetic range of organisms. The same …
Convergent evolution of defensin sequence, structure and function
Defensins are a well-characterised group of small, disulphide-rich, cationic peptides that are
produced by essentially all eukaryotes and are highly diverse in their sequences and …
produced by essentially all eukaryotes and are highly diverse in their sequences and …
Whole genome duplication and gene evolution in the hyperdiverse venomous gastropods
The diversity of venomous organisms and the toxins they produce have been increasingly
investigated, but taxonomic bias remains important. Neogastropods, a group of marine …
investigated, but taxonomic bias remains important. Neogastropods, a group of marine …
The rise and fall of an evolutionary innovation: contrasting strategies of venom evolution in ancient and young animals
Animal venoms are theorized to evolve under the significant influence of positive Darwinian
selection in a chemical arms race scenario, where the evolution of venom resistance in prey …
selection in a chemical arms race scenario, where the evolution of venom resistance in prey …
Restriction and recruitment—gene duplication and the origin and evolution of snake venom toxins
Snake venom has been hypothesized to have originated and diversified through a process
that involves duplication of genes encoding body proteins with subsequent recruitment of …
that involves duplication of genes encoding body proteins with subsequent recruitment of …
Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: Molecules, mechanisms and medicine
S Nirthanan - Biochemical pharmacology, 2020 - Elsevier
Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …
The evolution of venom by co-option of single-copy genes
The classic model for the evolution of novel gene function is through gene duplication
followed by evolution of a new function by one of the copies (neofunctionalization)[1, 2] …
followed by evolution of a new function by one of the copies (neofunctionalization)[1, 2] …
Coevolution takes the sting out of it: Evolutionary biology and mechanisms of toxin resistance in animals
Understanding how biotic interactions shape the genomes of the interacting species is a
long-sought goal of evolutionary biology that has been hampered by the scarcity of tractable …
long-sought goal of evolutionary biology that has been hampered by the scarcity of tractable …
Investigating toxin diversity and abundance in snake venom proteomes
T Tasoulis, TL Pukala, GK Isbister - Frontiers in Pharmacology, 2022 - frontiersin.org
Understanding snake venom proteomes is becoming increasingly important to understand
snake venom biology, evolution and especially clinical effects of venoms and approaches to …
snake venom biology, evolution and especially clinical effects of venoms and approaches to …