Gene duplication as a mechanism of genomic adaptation to a changing environment

FA Kondrashov - Proceedings of the Royal Society B …, 2012 - royalsocietypublishing.org
A subject of extensive study in evolutionary theory has been the issue of how neutral,
redundant copies can be maintained in the genome for long periods of time. Concurrently …

Venomics: integrative venom proteomics and beyond

JJ Calvete - Biochemical Journal, 2017 - portlandpress.com
Venoms are integrated phenotypes that evolved independently in, and are used for
predatory and defensive purposes by, a wide phylogenetic range of organisms. The same …

Convergent evolution of defensin sequence, structure and function

TMA Shafee, FT Lay, TK Phan, MA Anderson… - Cellular and Molecular …, 2017 - Springer
Defensins are a well-characterised group of small, disulphide-rich, cationic peptides that are
produced by essentially all eukaryotes and are highly diverse in their sequences and …

Whole genome duplication and gene evolution in the hyperdiverse venomous gastropods

S Farhat, MV Modica, N Puillandre - Molecular Biology and …, 2023 - academic.oup.com
The diversity of venomous organisms and the toxins they produce have been increasingly
investigated, but taxonomic bias remains important. Neogastropods, a group of marine …

The rise and fall of an evolutionary innovation: contrasting strategies of venom evolution in ancient and young animals

K Sunagar, Y Moran - PLoS genetics, 2015 - journals.plos.org
Animal venoms are theorized to evolve under the significant influence of positive Darwinian
selection in a chemical arms race scenario, where the evolution of venom resistance in prey …

Restriction and recruitment—gene duplication and the origin and evolution of snake venom toxins

AD Hargreaves, MT Swain, MJ Hegarty… - Genome biology and …, 2014 - academic.oup.com
Snake venom has been hypothesized to have originated and diversified through a process
that involves duplication of genes encoding body proteins with subsequent recruitment of …

Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: Molecules, mechanisms and medicine

S Nirthanan - Biochemical pharmacology, 2020 - Elsevier
Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …

The evolution of venom by co-option of single-copy genes

EO Martinson, YD Kelkar, CH Chang, JH Werren - Current Biology, 2017 - cell.com
The classic model for the evolution of novel gene function is through gene duplication
followed by evolution of a new function by one of the copies (neofunctionalization)[1, 2] …

Coevolution takes the sting out of it: Evolutionary biology and mechanisms of toxin resistance in animals

K Arbuckle, RCR de la Vega, NR Casewell - Toxicon, 2017 - Elsevier
Understanding how biotic interactions shape the genomes of the interacting species is a
long-sought goal of evolutionary biology that has been hampered by the scarcity of tractable …

Investigating toxin diversity and abundance in snake venom proteomes

T Tasoulis, TL Pukala, GK Isbister - Frontiers in Pharmacology, 2022 - frontiersin.org
Understanding snake venom proteomes is becoming increasingly important to understand
snake venom biology, evolution and especially clinical effects of venoms and approaches to …