Liposomes in cancer therapy: how did we start and where are we now

MD Fulton, W Najahi-Missaoui - International Journal of Molecular …, 2023 - mdpi.com
Since their first discovery in the 1960s by Alec Bangham, liposomes have been shown to be
effective drug delivery systems for treating various cancers. Several liposome-based …

Application of light scattering techniques to nanoparticle characterization and development

PM Carvalho, MR Felício, NC Santos… - Frontiers in …, 2018 - frontiersin.org
Over the years, the scientific importance of nanoparticles for biomedical applications has
increased. The high stability and biocompatibility, together with the low toxicity of the …

Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities

L Li, S Hu, X Chen - Biomaterials, 2018 - Elsevier
In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas
(CRISPR-associated) genome editing systems have become one of the most robust …

Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery

Y Fang, J Xue, S Gao, A Lu, D Yang, H Jiang, Y He… - Drug Delivery, 2017 - Taylor & Francis
To prolong the circulation time of drug, PEGylation has been widely used via the enhanced
permeability and retention (EPR) effect, thereby providing new hope for better treatment …

Cell penetrating peptides as molecular carriers for anti-cancer agents

A Borrelli, AL Tornesello, ML Tornesello… - Molecules, 2018 - mdpi.com
Cell membranes with their selective permeability play important functions in the tight control
of molecular exchanges between the cytosol and the extracellular environment as the …

Ligand-targeted liposome design: challenges and fundamental considerations

GT Noble, JF Stefanick, JD Ashley, T Kiziltepe… - Trends in …, 2014 - cell.com
Nanomedicine, particularly liposomal drug delivery, has expanded considerably over the
past few decades, and several liposomal drugs are already providing improved clinical …

Cell-penetrating peptides: breaking through to the other side

E Koren, VP Torchilin - Trends in molecular medicine, 2012 - cell.com
Cell-penetrating peptides (CPPs) have been previously shown to be powerful transport
vector tools for the intracellular delivery of a large variety of cargoes through the cell …

Stimulus-responsive liposomes for biomedical applications

AI Antoniou, S Giofrè, P Seneci, D Passarella… - Drug discovery today, 2021 - Elsevier
Liposomes are amphipathic lipidic supramolecular aggregates that are able to encapsulate
and carry molecules of both hydrophilic and hydrophobic nature. They have been widely …

[HTML][HTML] CRISPR/Cas9 gene editing: New hope for Alzheimer's disease therapeutics

S Bhardwaj, KK Kesari, M Rachamalla, S Mani… - Journal of Advanced …, 2022 - Elsevier
Background Alzheimer's disease (AD) is an insidious, irreversible, and progressive
neurodegenerative health condition manifesting as cognitive deficits and amyloid beta (Aβ) …

Effect of surface properties on liposomal siRNA delivery

Y **a, J Tian, X Chen - Biomaterials, 2016 - Elsevier
Liposomes are one of the most widely investigated carriers for siRNA delivery. The surface
properties of liposomal carriers, including the surface charge, PEGylation, and ligand …