The rapid kinetics of biological processes and associated short-lived conformational
changes pose a significant challenge in attempts to structurally visualize biomolecules …

The prokaryotic translation elongation factor P (EF-P) and the eukaryotic/archaeal
counterparts eIF5A/aIF5A are proteins that serve a crucial role in mitigating ribosomal …

In all living cells, the ribosome translates the genetic information carried by messenger
RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein …

The universally conserved process of protein biosynthesis is crucial for maintaining cellular
homoeostasis and in eukaryotes, mitochondrial translation is essential for aerobic energy …

The antibiotics chloramphenicol (CHL) and oxazolidinones, including linezolid (LZD), are
known to inhibit mitochondrial translation. This can result in serious, potentially deadly, side …

The spirochete bacterial pathogen Borrelia (Borreliella) burgdorferi (Bbu) affects more than
10% of the world population and causes Lyme disease in about half a million people in the …

The mammalian mitochondrial protein synthesis system produces 13 essential subunits of
oxidative phosphorylation (OXPHOS) complexes. Translation initiation in mammalian …

Mycobacterial HflX confers resistance against macrolide antibiotics. However, the exact
molecular mechanism is poorly understood. To gain further insights, we determined the cryo …

Mitochondria are the essential players in eukaryotic ATP production by oxidative
phosphorylation, which relies on the maintenance and accurate expression of the …

The rapid kinetics of biological processes and associated short-lived conformational
changes pose a significant challenge in attempts to structurally visualize biomolecules …