[HTML][HTML] Malaria parasite plasmepsins: More than just plain old degradative pepsins

AS Nasamu, AJ Polino, ES Istvan… - Journal of Biological …, 2020 - Elsevier
Plasmepsins are a group of diverse aspartic proteases in the malaria parasite Plasmodium.
Their functions are strikingly multifaceted, ranging from hemoglobin degradation to secretory …

Protein export into malaria parasite–infected erythrocytes: mechanisms and functional consequences

NJ Spillman, JR Beck… - Annual review of …, 2015 - annualreviews.org
Phylum Apicomplexa comprises a large group of obligate intracellular parasites of high
medical and veterinary importance. These organisms succeed intracellularly by effecting …

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

A Mbengue, S Bhattacharjee, T Pandharkar, H Liu… - Nature, 2015 - nature.com
Artemisinins are the cornerstone of anti-malarial drugs. Emergence and spread of resistance
to them,, raises risk of wi** out recent gains achieved in reducing worldwide malaria …

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells

M Franco, MW Panas, ND Marino, MCW Lee… - MBio, 2016 - journals.asm.org
The intracellular protozoan Toxoplasma gondii dramatically reprograms the transcriptome of
host cells it infects, including substantially up-regulating the host oncogene c-myc. By …

Uncovering common principles in protein export of malaria parasites

C Grüring, A Heiber, F Kruse, S Flemming, G Franci… - Cell host & …, 2012 - cell.com
For proliferation, the malaria parasite Plasmodium falciparum needs to modify the infected
host cell extensively. To achieve this, the parasite exports proteins containing a Plasmodium …

[HTML][HTML] Endoplasmic reticulum PI (3) P lipid binding targets malaria proteins to the host cell

S Bhattacharjee, RV Stahelin, KD Speicher… - Cell, 2012 - cell.com
Hundreds of effector proteins of the human malaria parasite Plasmodium falciparum
constitute a" secretome" carrying a host-targeting (HT) signal, which predicts their export …

Mediation of the transition from biotrophy to necrotrophy in hemibiotrophic plant pathogens by secreted effector proteins

SJ Lee, JKC Rose - Plant signaling & behavior, 2010 - Taylor & Francis
Hemibiotrophs, such as Phytophthora infestans, exhibit distinct phases of their life cycle: an
early asymptomatic biotrophic phase and a late necrotrophic stage that is characterized by …

Moving in and renovating: exporting proteins from Plasmodium into host erythrocytes

DE Goldberg, AF Cowman - Nature Reviews Microbiology, 2010 - nature.com
Malaria parasites live within erythrocytes in the host bloodstream and induce crucial
changes to these cells. By so doing, they can obtain the nutrients that they require for growth …

Genome‐wide survey and phylogenetic analysis of histone acetyltransferases and histone deacetylases of Plasmodium falciparum

A Kanyal, M Rawat, P Gurung, D Choubey… - The FEBS …, 2018 - Wiley Online Library
Malaria parasites can readily sense and adapt to environmental changes, thus making the
control and eradication of this disease difficult. Molecular studies have unraveled a very …

Wherever I may roam: protein and membrane trafficking in P. falciparum-infected red blood cells

M Deponte, HC Hoppe, MCS Lee, AG Maier… - Molecular and …, 2012 - Elsevier
Quite aside from its immense importance as a human pathogen, studies in recent years
have brought to light the fact that the malaria parasite Plasmodium falciparum is an …