Circuit mechanisms of Parkinson's disease

MM McGregor, AB Nelson - Neuron, 2019 - cell.com
Parkinson's disease (PD) is a complex, multi-system neurodegenerative disorder. The
second most common neurodegenerative disorder after Alzheimer's disease, it affects …

Motor symptoms in Parkinson's disease: A unified framework

AA Moustafa, S Chakravarthy, JR Phillips… - Neuroscience & …, 2016 - Elsevier
Parkinson's disease (PD) is characterized by a range of motor symptoms. Besides the
cardinal symptoms (akinesia and bradykinesia, tremor and rigidity), PD patients show …

Deep brain stimulation of symptom-specific networks in Parkinson's disease

N Rajamani, H Friedrich, K Butenko, T Dembek… - Nature …, 2024 - nature.com
Abstract Deep Brain Stimulation can improve tremor, bradykinesia, rigidity, and axial
symptoms in patients with Parkinson's disease. Potentially, improving each symptom may …

Neural signatures of hyperdirect pathway activity in Parkinson's disease

A Oswal, C Cao, CH Yeh, WJ Neumann… - Nature …, 2021 - nature.com
Parkinson's disease (PD) is characterised by the emergence of beta frequency oscillatory
synchronisation across the cortico-basal-ganglia circuit. The relationship between the …

Emerging technologies for improved deep brain stimulation

H Cagnan, T Denison, C McIntyre, P Brown - Nature biotechnology, 2019 - nature.com
Deep brain stimulation (DBS) is an effective treatment for common movement disorders and
has been used to modulate neural activity through delivery of electrical stimulation to key …

Beta burst dynamics in Parkinson's disease OFF and ON dopaminergic medication

G Tinkhauser, A Pogosyan, H Tan, DM Herz, AA Kühn… - Brain, 2017 - academic.oup.com
Exaggerated basal ganglia beta activity (13–35 Hz) is commonly found in patients with
Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of …

Mechanisms of deep brain stimulation

TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

Evolving concepts on bradykinesia

M Bologna, G Paparella, A Fasano, M Hallett… - Brain, 2020 - academic.oup.com
Bradykinesia is one of the cardinal motor symptoms of Parkinson's disease and other
parkinsonisms. The various clinical aspects related to bradykinesia and the …

Adaptive deep brain stimulation in advanced Parkinson disease

S Little, A Pogosyan, S Neal, B Zavala… - Annals of …, 2013 - Wiley Online Library
Objective Brain–computer interfaces (BCIs) could potentially be used to interact with
pathological brain signals to intervene and ameliorate their effects in disease states. Here …

Pathophysiology of motor dysfunction in Parkinson's disease as the rationale for drug treatment and rehabilitation

F Magrinelli, A Picelli, P Tocco, A Federico… - Parkinson's …, 2016 - Wiley Online Library
Cardinal motor features of Parkinson's disease (PD) include bradykinesia, rest tremor, and
rigidity, which appear in the early stages of the disease and largely depend on …