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Circuit mechanisms of Parkinson's disease
MM McGregor, AB Nelson - Neuron, 2019 - cell.com
Parkinson's disease (PD) is a complex, multi-system neurodegenerative disorder. The
second most common neurodegenerative disorder after Alzheimer's disease, it affects …
second most common neurodegenerative disorder after Alzheimer's disease, it affects …
Motor symptoms in Parkinson's disease: A unified framework
Parkinson's disease (PD) is characterized by a range of motor symptoms. Besides the
cardinal symptoms (akinesia and bradykinesia, tremor and rigidity), PD patients show …
cardinal symptoms (akinesia and bradykinesia, tremor and rigidity), PD patients show …
Deep brain stimulation of symptom-specific networks in Parkinson's disease
Abstract Deep Brain Stimulation can improve tremor, bradykinesia, rigidity, and axial
symptoms in patients with Parkinson's disease. Potentially, improving each symptom may …
symptoms in patients with Parkinson's disease. Potentially, improving each symptom may …
Neural signatures of hyperdirect pathway activity in Parkinson's disease
Parkinson's disease (PD) is characterised by the emergence of beta frequency oscillatory
synchronisation across the cortico-basal-ganglia circuit. The relationship between the …
synchronisation across the cortico-basal-ganglia circuit. The relationship between the …
Emerging technologies for improved deep brain stimulation
Deep brain stimulation (DBS) is an effective treatment for common movement disorders and
has been used to modulate neural activity through delivery of electrical stimulation to key …
has been used to modulate neural activity through delivery of electrical stimulation to key …
Beta burst dynamics in Parkinson's disease OFF and ON dopaminergic medication
Exaggerated basal ganglia beta activity (13–35 Hz) is commonly found in patients with
Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of …
Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of …
Mechanisms of deep brain stimulation
TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …
Evolving concepts on bradykinesia
Bradykinesia is one of the cardinal motor symptoms of Parkinson's disease and other
parkinsonisms. The various clinical aspects related to bradykinesia and the …
parkinsonisms. The various clinical aspects related to bradykinesia and the …
Adaptive deep brain stimulation in advanced Parkinson disease
S Little, A Pogosyan, S Neal, B Zavala… - Annals of …, 2013 - Wiley Online Library
Objective Brain–computer interfaces (BCIs) could potentially be used to interact with
pathological brain signals to intervene and ameliorate their effects in disease states. Here …
pathological brain signals to intervene and ameliorate their effects in disease states. Here …
Pathophysiology of motor dysfunction in Parkinson's disease as the rationale for drug treatment and rehabilitation
Cardinal motor features of Parkinson's disease (PD) include bradykinesia, rest tremor, and
rigidity, which appear in the early stages of the disease and largely depend on …
rigidity, which appear in the early stages of the disease and largely depend on …