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Role of biocatalysis in sustainable chemistry
Based on the principles and metrics of green chemistry and sustainable development,
biocatalysis is both a green and sustainable technology. This is largely a result of the …
biocatalysis is both a green and sustainable technology. This is largely a result of the …
Continuous‐flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients
In the past few years, continuous‐flow reactors with channel dimensions in the micro‐or
millimeter region have found widespread application in organic synthesis. The characteristic …
millimeter region have found widespread application in organic synthesis. The characteristic …
Reconfigurable system for automated optimization of diverse chemical reactions
Chemical synthesis generally requires labor-intensive, sometimes tedious trial-and-error
optimization of reaction conditions. Here, we describe a plug-and-play, continuous-flow …
optimization of reaction conditions. Here, we describe a plug-and-play, continuous-flow …
On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
Pharmaceutical manufacturing typically uses batch processing at multiple locations.
Disadvantages of this approach include long production times and the potential for supply …
Disadvantages of this approach include long production times and the potential for supply …
Flow chemistry: recent developments in the synthesis of pharmaceutical products
R Porta, M Benaglia, A Puglisi - Organic Process Research & …, 2016 - ACS Publications
Recently, application of the flow technologies for the preparation of fine chemicals, such as
natural products or Active Pharmaceutical Ingredients (APIs), has become very popular …
natural products or Active Pharmaceutical Ingredients (APIs), has become very popular …
Multi-step continuous-flow synthesis
Organic chemistry is continually evolving to improve the syntheses of value added and
bioactive compounds. Through this progression, a concomitant advancement in laboratory …
bioactive compounds. Through this progression, a concomitant advancement in laboratory …
Flow chemistry—microreaction technology comes of age
KF Jensen - AIChE Journal, 2017 - Wiley Online Library
Over the past two decades, microreaction technology has matured from early devices and
concepts to encompass a wide range of commercial equipment and applications. This …
concepts to encompass a wide range of commercial equipment and applications. This …
Integrated continuous pharmaceutical technologies—a review
Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …
and development of new active compounds; meanwhile, the structure of the production …
Continuous crystallization processes in pharmaceutical manufacturing: A review
J Orehek, D Teslic, B Likozar - Organic Process Research & …, 2020 - ACS Publications
This scientific paper presents an overview of continuous solution crystallization in the
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …
Organic synthesis: march of the machines
SV Ley, DE Fitzpatrick, RJ Ingham… - Angewandte Chemie …, 2015 - Wiley Online Library
Organic synthesis is changing; in a world where budgets are constrained and the
environmental impacts of practice are scrutinized, it is increasingly recognized that the …
environmental impacts of practice are scrutinized, it is increasingly recognized that the …