Role of biocatalysis in sustainable chemistry

RA Sheldon, JM Woodley - Chemical reviews, 2018 - ACS Publications
Based on the principles and metrics of green chemistry and sustainable development,
biocatalysis is both a green and sustainable technology. This is largely a result of the …

Continuous‐flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients

B Gutmann, D Cantillo… - Angewandte Chemie …, 2015 - Wiley Online Library
In the past few years, continuous‐flow reactors with channel dimensions in the micro‐or
millimeter region have found widespread application in organic synthesis. The characteristic …

Reconfigurable system for automated optimization of diverse chemical reactions

AC Bédard, A Adamo, KC Aroh, MG Russell… - Science, 2018 - science.org
Chemical synthesis generally requires labor-intensive, sometimes tedious trial-and-error
optimization of reaction conditions. Here, we describe a plug-and-play, continuous-flow …

On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

A Adamo, RL Beingessner, M Behnam, J Chen… - Science, 2016 - science.org
Pharmaceutical manufacturing typically uses batch processing at multiple locations.
Disadvantages of this approach include long production times and the potential for supply …

Flow chemistry: recent developments in the synthesis of pharmaceutical products

R Porta, M Benaglia, A Puglisi - Organic Process Research & …, 2016 - ACS Publications
Recently, application of the flow technologies for the preparation of fine chemicals, such as
natural products or Active Pharmaceutical Ingredients (APIs), has become very popular …

Multi-step continuous-flow synthesis

J Britton, CL Raston - Chemical Society Reviews, 2017 - pubs.rsc.org
Organic chemistry is continually evolving to improve the syntheses of value added and
bioactive compounds. Through this progression, a concomitant advancement in laboratory …

Flow chemistry—microreaction technology comes of age

KF Jensen - AIChE Journal, 2017 - Wiley Online Library
Over the past two decades, microreaction technology has matured from early devices and
concepts to encompass a wide range of commercial equipment and applications. This …

Integrated continuous pharmaceutical technologies—a review

A Domokos, B Nagy, B Szilágyi, G Marosi… - … Process Research & …, 2021 - ACS Publications
Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …

Continuous crystallization processes in pharmaceutical manufacturing: A review

J Orehek, D Teslic, B Likozar - Organic Process Research & …, 2020 - ACS Publications
This scientific paper presents an overview of continuous solution crystallization in the
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …

Organic synthesis: march of the machines

SV Ley, DE Fitzpatrick, RJ Ingham… - Angewandte Chemie …, 2015 - Wiley Online Library
Organic synthesis is changing; in a world where budgets are constrained and the
environmental impacts of practice are scrutinized, it is increasingly recognized that the …