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The role and regulation of integrins in cell migration and invasion
MR Chastney, J Kaivola, VM Leppänen… - … Reviews Molecular Cell …, 2025 - nature.com
Integrin receptors are the main molecular link between cells and the extracellular matrix
(ECM) as well as mediating cell–cell interactions. Integrin–ECM binding triggers the …
(ECM) as well as mediating cell–cell interactions. Integrin–ECM binding triggers the …
Forcing the code: tension modulates signaling to drive morphogenesis and malignancy
Abstract Development and disease are regulated by the interplay between genetics and the
signaling pathways stimulated by morphogens, growth factors, and cytokines. Experimental …
signaling pathways stimulated by morphogens, growth factors, and cytokines. Experimental …
[HTML][HTML] Integrating integrins with the hallmarks of cancer
Epithelial cells adhere to a specialized extracellular matrix called the basement membrane
which allows them to polarize and form epithelial tissues. The extracellular matrix provides …
which allows them to polarize and form epithelial tissues. The extracellular matrix provides …
Biomechanical properties of laminins and their impact on cancer progression
Laminins (LMs) constitute a family of heterotrimeric glycoproteins essential for the formation
of basement membranes (BM). They act as molecular bridges between cells and the …
of basement membranes (BM). They act as molecular bridges between cells and the …
Sha** epithelial tissues by stem cell mechanics in development and cancer
Adult stem cells balance self-renewal and differentiation to build, maintain and repair
tissues. The role of signalling pathways and transcriptional networks in controlling stem cell …
tissues. The role of signalling pathways and transcriptional networks in controlling stem cell …
[HTML][HTML] Myosin light chains in the progression of cancer
The myosin light chains (MLCs) of non-muscle myosin II are known to regulate cellular
architecture and generate cellular forces; they also have an increasingly emerging role in …
architecture and generate cellular forces; they also have an increasingly emerging role in …
[HTML][HTML] Cyclic stretch induced epigenetic activation of periodontal ligament cells
Periodontal ligament (PDL) cells play a crucial role in maintaining periodontal integrity and
function by providing cell sources for ligament regeneration. While biophysical stimulation is …
function by providing cell sources for ligament regeneration. While biophysical stimulation is …
Sliding Hydrogels Reveal the Modulation of Mechanosensing Attenuates the Inflammatory Phenotype of Osteoarthritic Chondrocytes in 3D
Osteoarthritis (OA) is a prevalen degenerative joint disease with no FDA‐approved
therapies that can halt or reverse its progression. Current treatments address symptoms like …
therapies that can halt or reverse its progression. Current treatments address symptoms like …
[HTML][HTML] Dynamic duo: Cell–extracellular matrix interactions in hair follicle development and regeneration
Ectodermal organs, such as hair follicles, originate from simple epithelial and mesenchymal
sheets through a complex developmental process driven by interactions between these cell …
sheets through a complex developmental process driven by interactions between these cell …
An eGFP-Col4a2 mouse model reveals basement membrane dynamics underlying hair follicle morphogenesis
Precisely controlled remodeling of the basement membrane (BM) is crucial for
morphogenesis, but its molecular and tissuelevel dynamics, underlying mechanisms, and …
morphogenesis, but its molecular and tissuelevel dynamics, underlying mechanisms, and …