The COVID-19 pandemic and Alzheimer's disease: mutual risks and mechanisms
Abstract Coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a life-threatening disease, especially …
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a life-threatening disease, especially …
Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies
Background To summarize modifiable factors for coronavirus disease 2019 (COVID-19)
suggested by Mendelian randomization studies. Methods In this systematic review, we …
suggested by Mendelian randomization studies. Methods In this systematic review, we …
An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms
W Sun, T Yang, F Sun, P Liu, J Gao, X Lan, W Xu… - Nature …, 2024 - nature.com
Evolutionary pressures sculpt population genetics, whereas immune adaptation fortifies
humans against life-threatening organisms. How the evolution of selective genetic variation …
humans against life-threatening organisms. How the evolution of selective genetic variation …
COVID‐19 and the impact on Alzheimer's disease pathology
Abstract Coronavirus disease 2019 (COVID‐19) has rapidly escalated into a global
pandemic that primarily affects older and immunocompromised individuals due to …
pandemic that primarily affects older and immunocompromised individuals due to …
The UK Biobank: A shining example of genome-wide association study science with the power to detect the murky complications of real-world epidemiology
VY Tan, NJ Timpson - Annual review of genomics and human …, 2022 - annualreviews.org
Genome-wide association studies (GWASs) have successfully identified thousands of
genetic variants that are reliably associated with human traits. Although GWASs are …
genetic variants that are reliably associated with human traits. Although GWASs are …
Host genetic factors, comorbidities and the risk of severe COVID-19
Abstract Background Coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), was varied in disease symptoms. We …
respiratory syndrome coronavirus 2 (SARS-CoV-2), was varied in disease symptoms. We …
Lineage-specific positive selection on ACE2 contributes to the genetic susceptibility of COVID-19
Abstract The Angiotensin-Converting Enzyme-2 (ACE2) gene, located on Xp22. 2, attracts a
great deal of attention because the protein it encodes is believed to be the functional cellular …
great deal of attention because the protein it encodes is believed to be the functional cellular …
Rare variants in inborn errors of immunity genes associated with covid-19 severity
Host genetic factors have been shown to play an important role in SARS-CoV-2 infection
and the course of Covid-19 disease. The genetic contributions of common variants …
and the course of Covid-19 disease. The genetic contributions of common variants …
Micronutrients, Vitamin D, and Inflammatory Biomarkers in COVID-19: A Systematic Review and Meta-analysis of Causal Inference Studies
Á Alcalá-Santiago, M Rodriguez-Barranco… - Nutrition …, 2024 - academic.oup.com
Context Experimental and observational studies suggest that circulating micronutrients,
including vitamin D (VD), may increase COVID-19 risk and its associated outcomes …
including vitamin D (VD), may increase COVID-19 risk and its associated outcomes …
Nature of Acquired Immune Responses, Epitope Specificity and Resultant Protection from SARS-CoV-2
RM Gorczynski, RA Lindley, EJ Steele… - Journal of Personalized …, 2021 - mdpi.com
The primary global response to the SARS-CoV-2 pandemic has been to bring to the clinic as
rapidly as possible a number of vaccines that are predicted to enhance immunity to this viral …
rapidly as possible a number of vaccines that are predicted to enhance immunity to this viral …