Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies

A Thakur, R Singla, V Jaitak - European journal of medicinal chemistry, 2015 - Elsevier
Coumarins are fused benzene and pyrone ring systems which prompt biological
investigation to assess their potential therapeutic significance. It possesses immeasurable …

Recent developments of C-4 substituted coumarin derivatives as anticancer agents

J Dandriyal, R Singla, M Kumar, V Jaitak - European journal of medicinal …, 2016 - Elsevier
Cancer is a prominent cause of death in global. Currently, the numbers of drugs that are in
clinical practice are having a high prevalence of side effect and multidrug resistance …

Pechmann reaction in the synthesis of coumarin derivatives

MM Heravi, S Khaghaninejad, M Mostofi - Advances in heterocyclic …, 2014 - Elsevier
The Pechmann reaction introduces one of the most significant and simple methods for the
synthesis of a variety of heterocyclic compounds, particularly coumarin derivatives. In 1883 …

Mechanochemical synthesis of coumarins via Pechmann condensation under solvent-free conditions: An easy access to coumarins and annulated pyrano [2, 3-f] and …

AD Sharapov, RF Fatykhov, IA Khalymbadzha… - Green …, 2022 - pubs.rsc.org
A green protocol has been developed for the synthesis of simple coumarins and linear
pyrano [2, 3-f] and [3, 2-f] indoles by the reaction of phenol derivatives with β-ketoesters …

Heterogeneously Catalyzed Pechmann Condensation Employing the Tailored Zn0.925Ti0.075O NPs: Synthesis of Coumarin

NH Jadhav, SS Sakate, NK Rasal, DR Shinde… - ACS …, 2019 - ACS Publications
A novel heterogeneous catalytic method was developed for the synthesis of coumarin and
its derivatives using the Ti (IV)-doped ZnO matrix forming catalyst Zn0. 925Ti0. 075O having …

Recent advances in the synthesis of coumarin derivatives via Pechmann condensation

AS Zambare, FA Kalam Khan… - Current Organic …, 2016 - ingentaconnect.com
The Pechmann condensation is the formation of coumarin derivatives from phenols and a
carboxylic acids or esters containing a β-carbonyl group under acidic conditions. The …

[HTML][HTML] FeCl3-catalysed ultrasonic-assisted, solvent-free synthesis of 4-substituted coumarins. A useful complement to the Pechmann reaction

KC Prousis, N Avlonitis, GA Heropoulos… - Ultrasonics …, 2014 - Elsevier
The catalytic activity of FeCl 3 for the synthesis of a variety of 4-substituted coumarins using
high energy techniques has been investigated. The ultrasonic-assisted conditions provide a …

Pentafluorophenylammonium triflate as an efficient, environmentally friendly and novel organocatalyst for synthesis of bis-indolyl methane derivatives

S Khaksar, SM Ostad - Journal of Fluorine Chemistry, 2011 - Elsevier
A simple, inexpensive, environmentally friendly and efficient route for the synthesis of bis-
indolyl methane derivatives by the reaction of indole or N-methyl indole with aldehydes …

Establishing a flow process to Coumarin‐8‐carbaldehydes as important synthetic scaffolds

J Zak, D Ron, E Riva, HP Harding… - … A European Journal, 2012 - Wiley Online Library
Despite their usefulness as fluorophores and synthetic precursors, efficient and reliable
routes to coumarin‐8‐carbaldehydes are lacking. We describe here a high‐yielding …

Synthesis and biological properties of coumarin analogue: A brief Review

D Chaudhary, P Bedi, S Santra… - Letters in Organic …, 2022 - benthamdirect.com
One of the most prominent aromatic organic chemical compound is Coumarin having
formula C9H6O2 which is widely known for its benefits in drug industry. Colourless …