A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …

Various nutritional, behavioral, and pharmacological interventions have been previously
shown to extend life span in diverse model organisms, including Saccharomyces cerevisiae …

Increasing evidence indicates that reactive oxygen species (ROS), consisting of superoxide,
hydrogen peroxide, and multiple others, do not only cause oxidative stress, but rather may …

Increased oxidative stress has been associated with the aging process. However, recent
studies have revealed that a low-level oxidative stress can even extend the lifespan of …

In this review, it is our aim 1) to describe the high diversity in molecular and structural
antioxidant defenses against oxidative stress in animals, 2) to extend the traditional concept …

Mitochondria play a wide diversity of roles in cell physiology and have a key functional
implication in cell bioenergetics and biology of free radicals. As the main cellular source of …

Both endogenous processes and exogenous physical and chemical sources generate
deoxyribonucleic acid (DNA) damage in the nucleus and organelles of living cells. To …

Aging can be viewed as a quasi-programmed phenomenon driven by the overactivation of
the nutrient-sensing mTOR gerogene. mTOR-driven aging can be triggered or accelerated …

Testing the predictions of the Mitochondrial Free Radical Theory of Ageing (MFRTA) has
provided a deep understanding of the role of reactive oxygen species (ROS) and …

The mechanisms underlying ageing have been discussed for decades, and advances in
molecular and cell biology of the last three decades have accelerated research in this area …