[HTML][HTML] The CRISPR-Cas toolbox and gene editing technologies
G Liu, Q Lin, S **, C Gao - Molecular cell, 2022 - cell.com
The emergence of CRISPR-Cas systems has accelerated the development of gene editing
technologies, which are widely used in the life sciences. To improve the performance of …
technologies, which are widely used in the life sciences. To improve the performance of …
Structural biology of CRISPR–Cas immunity and genome editing enzymes
CRISPR–Cas systems provide resistance against foreign mobile genetic elements and have
a wide range of genome editing and biotechnological applications. In this Review, we …
a wide range of genome editing and biotechnological applications. In this Review, we …
The next generation of CRISPR–Cas technologies and applications
A Pickar-Oliver, CA Gersbach - Nature reviews Molecular cell biology, 2019 - nature.com
The prokaryote-derived CRISPR–Cas genome editing systems have transformed our ability
to manipulate, detect, image and annotate specific DNA and RNA sequences in living cells …
to manipulate, detect, image and annotate specific DNA and RNA sequences in living cells …
Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering
Microbial systems underpin many biotechnologies, including CRISPR, but the exponential
growth of sequence databases makes it difficult to find previously unidentified systems. In …
growth of sequence databases makes it difficult to find previously unidentified systems. In …
A time-resolved, multi-symbol molecular recorder via sequential genome editing
DNA is naturally well suited to serve as a digital medium for in vivo molecular recording.
However, contemporary DNA-based memory devices are constrained in terms of the …
However, contemporary DNA-based memory devices are constrained in terms of the …
The biology of CRISPR-Cas: backward and forward
F Hille, H Richter, SP Wong, M Bratovič, S Ressel… - Cell, 2018 - cell.com
In bacteria and archaea, clustered regularly interspaced short palindromic repeats
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …
Molecular digital data storage using DNA
Molecular data storage is an attractive alternative for dense and durable information storage,
which is sorely needed to deal with the growing gap between information production and the …
which is sorely needed to deal with the growing gap between information production and the …
DNA sequencing at 40: past, present and future
This review commemorates the 40th anniversary of DNA sequencing, a period in which we
have already witnessed multiple technological revolutions and a growth in scale from a few …
have already witnessed multiple technological revolutions and a growth in scale from a few …
Applications of CRISPR technologies in research and beyond
Programmable DNA cleavage using CRISPR–Cas9 enables efficient, site-specific genome
engineering in single cells and whole organisms. In the research arena, versatile CRISPR …
engineering in single cells and whole organisms. In the research arena, versatile CRISPR …
Noninvasive assessment of gut function using transcriptional recording sentinel cells
Transcriptional recording by CRISPR spacer acquisition from RNA endows engineered
Escherichia coli with synthetic memory, which through Record-seq reveals transcriptome …
Escherichia coli with synthetic memory, which through Record-seq reveals transcriptome …