STK11/LKB1 Modulation of the Immune Response in Lung Cancer: From Biology to Therapeutic Impact
The STK11/LKB1 gene codes for liver kinase B1 (STK11/LKB1), a highly conserved
serine/threonine kinase involved in many energy-related cellular processes. The canonical …
serine/threonine kinase involved in many energy-related cellular processes. The canonical …
Platelet and cancer-cell interactions modulate cancer-associated thrombosis risk in different cancer types
AL Palacios-Acedo, M Langiu, L Crescence, D Mège… - Cancers, 2022 - mdpi.com
Simple Summary Cancer-associated thrombosis is the first cause of death in cancer after
cancer-progression itself; however, thrombotic risk is not the same in all cancer types. Here …
cancer-progression itself; however, thrombotic risk is not the same in all cancer types. Here …
Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non–Small Cell Lung Cancer and Is …
N Pore, S Wu, N Standifer, M Jure-Kunkel… - Cancer Discovery, 2021 - AACR
Mutations in the STK11 (LKB1) gene regulate resistance to PD-1/PD-L1 blockade. This
study evaluated this association in patients with nonsquamous non–small cell lung cancer …
study evaluated this association in patients with nonsquamous non–small cell lung cancer …
A conserved role for AMP-activated protein kinase in NGLY1 deficiency
Mutations in human N-glycanase 1 (NGLY1) cause the first known congenital disorder of
deglycosylation (CDDG). Patients with this rare disease, which is also known as NGLY1 …
deglycosylation (CDDG). Patients with this rare disease, which is also known as NGLY1 …
The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progression
J Kang, S Gallucci, J Pan, JS Oakhill… - Frontiers in Cell and …, 2024 - frontiersin.org
STK11 (serine-threonine kinase 11), also known as LKB1 (liver kinase B1) is a highly
conserved master kinase that regulates cellular metabolism and polarity through a complex …
conserved master kinase that regulates cellular metabolism and polarity through a complex …
Posttranslational regulation of liver kinase B1 in human cancer
Liver kinase B1 (LKB1) is a serine-threonine kinase that participates in multiple cellular and
biological processes, including energy metabolism, cell polarity, cell proliferation, cell …
biological processes, including energy metabolism, cell polarity, cell proliferation, cell …
LKB1: Can we target an hidden target? Focus on NSCLC
G Ndembe, I Intini, E Perin, M Marabese… - Frontiers in …, 2022 - frontiersin.org
LKB1 (liver kinase B1) is a master regulator of several processes such as metabolism,
proliferation, cell polarity and immunity. About one third of non-small cell lung cancers …
proliferation, cell polarity and immunity. About one third of non-small cell lung cancers …
Loss of STK11 Suppresses Lipid Metabolism and Attenuates KRAS-Induced Immunogenicity in Patients with Non–Small Cell Lung Cancer
DR Principe, MM Pasquinelli, RH Nguyen… - Cancer Research …, 2024 - aacrjournals.org
As many as 30% of the patients with non–small cell lung cancer harbor oncogenic KRAS
mutations, which leads to extensive remodeling of the tumor immune microenvironment …
mutations, which leads to extensive remodeling of the tumor immune microenvironment …
[HTML][HTML] Targeted therapy approaches for epithelial-mesenchymal transition in triple negative breast cancer
Triple-negative breast cancer (TNBC) is distinguished by negative expression of estrogen
receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 …
receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 …
Genomic characterization of hepatoid tumors: context matters
RT Lawlor, A Mafficini, C Sciammarella, C Cantù… - Human Pathology, 2021 - Elsevier
Hepatoid tumors (HT) are rare neoplasms morphologically resembling hepatocellular
carcinoma, which arise in several organs other than the liver. A comprehensive molecular …
carcinoma, which arise in several organs other than the liver. A comprehensive molecular …