STK11/LKB1 Modulation of the Immune Response in Lung Cancer: From Biology to Therapeutic Impact

E Pons-Tostivint, A Lugat, JF Fontenau, MG Denis… - Cells, 2021 - mdpi.com
The STK11/LKB1 gene codes for liver kinase B1 (STK11/LKB1), a highly conserved
serine/threonine kinase involved in many energy-related cellular processes. The canonical …

Platelet and cancer-cell interactions modulate cancer-associated thrombosis risk in different cancer types

AL Palacios-Acedo, M Langiu, L Crescence, D Mège… - Cancers, 2022 - mdpi.com
Simple Summary Cancer-associated thrombosis is the first cause of death in cancer after
cancer-progression itself; however, thrombotic risk is not the same in all cancer types. Here …

Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non–Small Cell Lung Cancer and Is …

N Pore, S Wu, N Standifer, M Jure-Kunkel… - Cancer Discovery, 2021 - AACR
Mutations in the STK11 (LKB1) gene regulate resistance to PD-1/PD-L1 blockade. This
study evaluated this association in patients with nonsquamous non–small cell lung cancer …

A conserved role for AMP-activated protein kinase in NGLY1 deficiency

SY Han, A Pandey, T Moore, A Galeone… - PLoS …, 2020 - journals.plos.org
Mutations in human N-glycanase 1 (NGLY1) cause the first known congenital disorder of
deglycosylation (CDDG). Patients with this rare disease, which is also known as NGLY1 …

The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progression

J Kang, S Gallucci, J Pan, JS Oakhill… - Frontiers in Cell and …, 2024 - frontiersin.org
STK11 (serine-threonine kinase 11), also known as LKB1 (liver kinase B1) is a highly
conserved master kinase that regulates cellular metabolism and polarity through a complex …

Posttranslational regulation of liver kinase B1 in human cancer

L Hu, M Liu, B Tang, Q Li, BS Pan, C Xu… - Journal of Biological …, 2023 - ASBMB
Liver kinase B1 (LKB1) is a serine-threonine kinase that participates in multiple cellular and
biological processes, including energy metabolism, cell polarity, cell proliferation, cell …

LKB1: Can we target an hidden target? Focus on NSCLC

G Ndembe, I Intini, E Perin, M Marabese… - Frontiers in …, 2022 - frontiersin.org
LKB1 (liver kinase B1) is a master regulator of several processes such as metabolism,
proliferation, cell polarity and immunity. About one third of non-small cell lung cancers …

Loss of STK11 Suppresses Lipid Metabolism and Attenuates KRAS-Induced Immunogenicity in Patients with Non–Small Cell Lung Cancer

DR Principe, MM Pasquinelli, RH Nguyen… - Cancer Research …, 2024 - aacrjournals.org
As many as 30% of the patients with non–small cell lung cancer harbor oncogenic KRAS
mutations, which leads to extensive remodeling of the tumor immune microenvironment …

[HTML][HTML] Targeted therapy approaches for epithelial-mesenchymal transition in triple negative breast cancer

M Haque, RK Shyanti, MK Mishra - Frontiers in Oncology, 2024 - pmc.ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC) is distinguished by negative expression of estrogen
receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 …

Genomic characterization of hepatoid tumors: context matters

RT Lawlor, A Mafficini, C Sciammarella, C Cantù… - Human Pathology, 2021 - Elsevier
Hepatoid tumors (HT) are rare neoplasms morphologically resembling hepatocellular
carcinoma, which arise in several organs other than the liver. A comprehensive molecular …