Interaction of metal complexes with G‐quadruplex DNA

SN Georgiades, NH Abd Karim… - Angewandte Chemie …, 2010 - Wiley Online Library
Guanine‐rich sequences of DNA can assemble into tetrastranded structures known as G‐
quadruplexes. It has been suggested that these secondary DNA structures could be …

Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes

JL Huppert - Chemical Society Reviews, 2008 - pubs.rsc.org
There are many structures that can be adopted by nucleic acids other than the famous
Watson–Crick duplex form. This tutorial review describes the guanine rich G-quadruplex …

Structure, location and interactions of G‐quadruplexes

JL Huppert - The FEBS journal, 2010 - Wiley Online Library
Four‐stranded G‐rich DNA structures called G‐quadruplexes have been the subject of
increasing interest recently. Experimental and computational techniques have been used to …

Chemical-biology approaches to probe DNA and RNA G-quadruplex structures in the genome

F Raguseo, S Chowdhury, A Minard… - Chemical …, 2020 - pubs.rsc.org
G-quadruplexes are nucleic acids secondary structures that can be formed in guanine-rich
sequences. More than 30 years ago, their formation was first observed in telomeric DNA …

Hunting G-quadruplexes

JL Huppert - Biochimie, 2008 - Elsevier
Whilst DNA spends much of its time in the double-stranded form, frequently in storage,
wrapped around histones and packaged as chromatin, it can also form other complex …

Co-transcriptional formation of DNA:RNA hybrid G-quadruplex and potential function as constitutional cis element for transcription control

K Zheng, S **ao, J Liu, J Zhang, Y Hao… - Nucleic acids …, 2013 - academic.oup.com
G-quadruplex formation in genomic DNA is considered to regulate transcription. Previous
investigations almost exclusively focused on intramolecular G-quadruplexes formed by DNA …

[HTML][HTML] TMPyP4 promotes cancer cell migration at low doses, but induces cell death at high doses

XH Zheng, X Nie, HY Liu, YM Fang, Y Zhao, LX **a - Scientific reports, 2016 - nature.com
TMPyP4 is widely considered as a potential photosensitizer in photodynamic therapy and a
G-quadruplex stabilizer for telomerase-based cancer therapeutics. However, its biological …

Tridentate N‐Donor Palladium (II) Complexes as Efficient Coordinating Quadruplex DNA Binders

E Largy, F Hamon, F Rosu, V Gabelica… - … A European Journal, 2011 - Wiley Online Library
Fifteen complexes of palladium, platinum, and copper, featuring five different N‐donor
tridentate (terpyridine‐like) ligands, were prepared with the aim of testing their G …

Nucleic acid-metal ion interactions

NV Hud - 2009 - books.google.com
Natural biochemical processes are routinely being discovered in living cells that involve
RNA. Some of these processes, such as RNA interference, are now being exploited for …

Molecular mechanisms of congenital heart disease

H **g-bin, L Ying-long, S Pei-wu, L **ao-dong… - Cardiovascular …, 2010 - Elsevier
BACKGROUND: Congenital heart disease (CHD) is the most common type of birth defect.
Despite the many advances in our understanding of cardiac development and many genes …