Evolution of the human pathogenic lifestyle in fungi

A Rokas - Nature Microbiology, 2022 - nature.com
Fungal pathogens cause more than a billion human infections every year, resulting in more
than 1.6 million deaths annually. Understanding the natural history and evolutionary ecology …

Soil Aspergillus Species, Pathogenicity and Control Perspectives

QN Nji, OO Babalola, M Mwanza - Journal of Fungi, 2023 - mdpi.com
Five Aspergillus sections have members that are established agricultural pests and
producers of different metabolites, threatening global food safety. Most of these pathogenic …

The pan-genome of Aspergillus fumigatus provides a high-resolution view of its population structure revealing high levels of lineage-specific diversity driven by …

LA Lofgren, BS Ross, RA Cramer, JE Stajich - PLoS Biology, 2022 - journals.plos.org
Aspergillus fumigatus is a deadly agent of human fungal disease where virulence
heterogeneity is thought to be at least partially structured by genetic variation between …

Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts

DA Opulente, AL LaBella, MC Harrison, JF Wolters… - Science, 2024 - science.org
Organisms exhibit extensive variation in ecological niche breadth, from very narrow
(specialists) to very broad (generalists). Two general paradigms have been proposed to …

Genome-scale phylogeny and contrasting modes of genome evolution in the fungal phylum Ascomycota

XX Shen, JL Steenwyk, AL LaBella, DA Opulente… - Science …, 2020 - science.org
Ascomycota, the largest and most well-studied phylum of fungi, contains three subphyla:
Saccharomycotina (budding yeasts), Pezizomycotina (filamentous fungi), and …

Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of Virulence Across Aspergillus Species

JL Steenwyk, ME Mead, SL Knowles, HA Raja… - Genetics, 2020 - academic.oup.com
Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of
Virulence Across Aspergillus Species | Genetics | Oxford Academic Skip to Main Content …

Know the enemy and know yourself: addressing cryptic fungal pathogens of humans and beyond

JL Steenwyk, A Rokas, GH Goldman - PLoS Pathogens, 2023 - journals.plos.org
“If you know the enemy and know yourself, you need not fear the result of a hundred battles.
If you know yourself but not the enemy, for every victory gained you will also suffer a defeat …

Aspergillus fumigatus conidial surface-associated proteome reveals factors for fungal evasion and host immunity modulation

CF Pinzan, C Valero, PA de Castro, JL da Silva… - Nature …, 2024 - nature.com
Aspergillus fumigatus causes aspergillosis and relies on asexual spores (conidia) for
initiating host infection. There is scarce information about A. fumigatus proteins involved in …

Genomic and phenotypic analysis of COVID-19-associated pulmonary aspergillosis isolates of Aspergillus fumigatus

JL Steenwyk, ME Mead, PA de Castro… - Microbiology …, 2021 - Am Soc Microbiol
The ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), first described in …

Pathogenic allodiploid hybrids of Aspergillus fungi

JL Steenwyk, AL Lind, LNA Ries, TF Dos Reis, LP Silva… - Current Biology, 2020 - cell.com
Interspecific hybridization substantially alters genotypes and phenotypes and can give rise
to new lineages. Hybrid isolates that differ from their parental species in infection-relevant …