All microorganisms are exposed to periodic stresses that inhibit growth. Many bacteria and
fungi weather these periods by entering a hardy, nonreplicating state, often termed …

Many properties of complex networks cannot be understood from monitoring the
components—not even when comprehensively monitoring all protein or metabolite …

Turnover numbers, also known as k cat values, are fundamental properties of enzymes.
However, k cat data are scarce and measured in vitro, thus may not faithfully represent the in …

Sortilin (∼ 95 kDa) is a member of the recently discovered family of Vps10p-domain
receptors,, and is expressed in a variety of tissues, notably brain, spinal cord and muscle. It …

A significant goal in the post-genome era is to relate the annotated genome sequence to the
physiological functions of a cell. Working from the annotated genome sequence, as well as …

Pentose phosphate pathway and isocitrate dehydrogenase are generally considered to be
the major sources of the anabolic reductant NADPH. As one of very few microbes …

In many organisms, metabolite interconversion at the phosphoenolpyruvate (PEP)–pyruvate–
oxaloacetate node involves a structurally entangled set of reactions that interconnects the …

Metabolic adaptation to the host environment is a defining feature of the pathogenicity of
Mycobacterium tuberculosis (Mtb), but we lack biochemical knowledge of its metabolic …

Application of metabolic engineering principles to the rational design of microbial production
processes crucially depends on the ability to describe quantitatively the systemic behavior of …

Cellular metabolism, the integrated interconversion of thousands of metabolic substrates
through enzyme-catalysed biochemical reactions, is the most investigated complex …