Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …

Primary cilia act as antenna receivers of environmental signals and enable effective
neuronal or glial responses. Disruption of their function is associated with circuit disorders …

The suprachiasmatic nucleus (SCN) drives circadian clock coherence through intercellular
coupling, which is resistant to environmental perturbations. We report that primary cilia are …

Astrocyte diversity is greatly influenced by local environmental modulation. Here we report
that the majority of astrocytes across the mouse brain possess a singular primary cilium …

Analysis of brain structure, connectivity, and molecular diversity relies on effective tissue
fixation. Conventional tissue fixation causes extracellular space (ECS) loss, complicating the …

Volume electron microscopy is the method of choice for the in situ interrogation of cellular
ultrastructure at the nanometer scale, and with the increase in large raw image datasets …

Serotonin is a neurotransmitter involved in the modulation of a multitude of physiological
and behavioral processes. In spite of the relatively reduced number of serotonin-producing …

Astrocytes, often considered as secondary responders to neurodegeneration, are emerging
as primary drivers of brain disease. Here we show that mitochondrial DNA depletion in …

Many neurons in the central nervous system produce a single primary cilium that serves as a
specialized signaling organelle. Several neuromodulatory G-protein-coupled receptors …