The eye is regarded as an immune privileged site. Since the presence of a vasculature
would impair vision, the vasculature of the eye is located outside of the central light path. As …

Wound healing is one of the most complex biological processes to occur in life. Repair of
tissue following injury involves dynamic interactions between multiple cell types, growth …

Glaucoma is a neurodegenerative disease that features the death of retinal ganglion cells
(RGCs) in the retina, often as a result of prolonged increases in intraocular pressure. We …

Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …

Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the
precise roles are not known. Understanding these complex processes, which may also be a …

Retinal degenerative diseases are major causes of vision loss and blindness worldwide and
are characterized by chronic and progressive neuronal loss. One common feature of retinal …

Glaucoma is a multifactorial neurodegenerative disorder affecting 80 million people
worldwide. Loss of retinal ganglion cells and degeneration of their axons in the optic nerve …

The role of microglia in degenerative and regenerative processes after damage of the
nervous system remains ambiguous, partially due to the paucity of appropriate investigative …

Background Glaucoma is a complex, multifactorial disease characterised by the loss of
retinal ganglion cells and their axons leading to a decrease in visual function. The earliest …

Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic
targets based on neuronal protection, repair, or regeneration, independent of etiology or site …