Applying a high voltage to a liquid passing through a capillary disintegrates the liquid
meniscus to generate a fine spray of charged droplets. As the droplets evaporate, polar …

Proteoforms, which arise from post-translational modifications, genetic polymorphisms and
RNA splice variants, play a pivotal role as drivers in biology. Understanding proteoforms is …

Top-down mass spectrometry (MS)-based proteomics is a powerful technology for
comprehensively characterizing proteoforms to decipher post-translational modifications …

Top-down proteomics (TDP) aims to identify and profile intact protein forms (proteoforms)
extracted from biological samples. True proteoform characterization requires that both the …

The combination of native electrospray ionization with top-down fragmentation in mass
spectrometry (MS) allows simultaneous determination of the stoichiometry of noncovalent …

Introduction-A better understanding of the underlying molecular mechanism of diseases is
critical for develo** more effective diagnostic tools and therapeutics toward precision …

Single-cell proteomics has emerged as a powerful method to characterize cellular
phenotypic heterogeneity and the cell-specific functional networks underlying biological …

In biology, it can be argued that if the genome contains the script for a cell's life cycle, then
the proteome constitutes an ensemble cast of actors that brings these instructions to life …

Systemic AL amyloidosis is a rare disease that is caused by the misfolding of
immunoglobulin light chains (LCs). Potential drivers of amyloid formation in this disease are …

Systemic ATTR amyloidosis is an increasingly important protein misfolding disease that is
provoked by the formation of amyloid fibrils from transthyretin protein. The pathological and …