Macrophage diversity in cancer revisited in the era of single-cell omics
RY Ma, A Black, BZ Qian - Trends in immunology, 2022 - cell.com
Tumor-associated macrophages (TAMs) have multiple potent functions in cancer and, thus,
represent important therapeutic targets. These diverse functions highlight the heterogenous …
represent important therapeutic targets. These diverse functions highlight the heterogenous …
Regulatory cells and the effect of cancer immunotherapy
M Iglesias-Escudero, N Arias-González… - Molecular cancer, 2023 - Springer
Several mechanisms and cell types are involved in the regulation of the immune response.
These include mostly regulatory T cells (Tregs), regulatory macrophages (Mregs), myeloid …
These include mostly regulatory T cells (Tregs), regulatory macrophages (Mregs), myeloid …
Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1
K Chamoto, T Yaguchi, M Tajima, T Honjo - Nature Reviews …, 2023 - nature.com
PD1 was originally discovered in 1992 as a molecule associated with activation-induced cell
death in T cells. Over the past 30 years, it was found that PD1 has a critical role in avoiding …
death in T cells. Over the past 30 years, it was found that PD1 has a critical role in avoiding …
[HTML][HTML] Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy
Y Xu, J ** the Tumor Immune Microenvironment Based on a Light‐Activated Nanoplatform for Efficient Cancer Therapy
Z Yang, Y Luo, H Yu, K Liang, M Wang… - Advanced …, 2022 - Wiley Online Library
The immunosuppressive tumor microenvironment (TME) always causes poor antitumor
immune efficacy, prone to relapse and metastasis. Herein, novel poly (vinylpyrrolidone)(PVP …
immune efficacy, prone to relapse and metastasis. Herein, novel poly (vinylpyrrolidone)(PVP …
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
I Nasir, C McGuinness, AR Poh, M Ernst, PK Darcy… - Trends in …, 2023 - cell.com
Macrophages represent a key component of the tumor microenvironment (TME) and are
largely associated with poor prognosis. Therapeutic targeting of macrophages has …
largely associated with poor prognosis. Therapeutic targeting of macrophages has …
Chirality‐Dependent Reprogramming of Macrophages by Chiral Nanozymes
Y Zhang, T Cui, J Yang, Y Huang… - Angewandte Chemie …, 2023 - Wiley Online Library
It is known that extracellular free radical reactive oxygen species (ROS) rather than
intracellular ROS plays a non‐substitutable role in regulation of tumor‐suppressing (M1) …
intracellular ROS plays a non‐substitutable role in regulation of tumor‐suppressing (M1) …
Mitochondrial metabolism mediated macrophage polarization in chronic lung diseases
T Dong, X Chen, H Xu, Y Song, H Wang, Y Gao… - Pharmacology & …, 2022 - Elsevier
As the first line of defence in the lung, alveolar macrophage contributes to maintaining lung
immune homoeostasis. Characterized by the heterogeneity and plasticity, macrophages …
immune homoeostasis. Characterized by the heterogeneity and plasticity, macrophages …