A compendium of mutational cancer driver genes
A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to develo** more efficient cancer detection methods and …
transformation. This is key to develo** more efficient cancer detection methods and …
State-of-the-art strategies for targeting the DNA damage response in cancer
Genomic instability is a key hallmark of cancer that arises owing to defects in the DNA
damage response (DDR) and/or increased replication stress. These alterations promote the …
damage response (DDR) and/or increased replication stress. These alterations promote the …
Genome-wide association studies of cancer: current insights and future perspectives
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
Transcriptome profiling revealed multiple genes and ECM-receptor interaction pathways that may be associated with breast cancer
Y Bao, L Wang, L Shi, F Yun, X Liu, Y Chen… - Cellular & molecular …, 2019 - Springer
Background Exploration of the genes with abnormal expression during the development of
breast cancer is essential to provide a deeper understanding of the mechanisms involved …
breast cancer is essential to provide a deeper understanding of the mechanisms involved …
[HTML][HTML] Genetics of breast cancer: a topic in evolution
S Shiovitz, LA Korde - Annals of Oncology, 2015 - Elsevier
ABSTRACT A hereditary predisposition to breast cancer significantly influences screening
and follow-up recommendations for high-risk women. However, in patients with a suggestive …
and follow-up recommendations for high-risk women. However, in patients with a suggestive …
BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2
The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance
for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly …
for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly …
Effect of BRCA germline mutations on breast cancer prognosis: A systematic review and meta-analysis
Z Baretta, S Mocellin, E Goldin, OI Olopade, D Huo - Medicine, 2016 - journals.lww.com
Background: The contribution of BRCA germline mutational status to breast cancer patients'
prognosis is unclear. We aimed to systematically review and perform meta-analysis of the …
prognosis is unclear. We aimed to systematically review and perform meta-analysis of the …
A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1
Y Miki, J Swensen, D Shattuck-Eidens, PA Futreal… - Science, 1994 - science.org
A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast
and ovarian cancer, has been identified by positional cloning methods. Probable …
and ovarian cancer, has been identified by positional cloning methods. Probable …
Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition
Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …
prognosis of the affected patient. Genomic instability arises from many different pathways …
Identification of the breast cancer susceptibility gene BRCA2
R Wooster, G Bignell, J Lancaster, S Swift, S Seal… - Nature, 1995 - nature.com
IN Western Europe and the United States approximately 1 in 12 women develop breast
cancer. A small proportion of breast cancer cases, in particular those arising at a young age …
cancer. A small proportion of breast cancer cases, in particular those arising at a young age …