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Sexual circuitry in Drosophila
Highlights•Sex-specific isoforms of Fruitless and Doublesex define dimorphic
circuitry.•Sensory pathways for chemical and auditory stimuli traced to the central …
circuitry.•Sensory pathways for chemical and auditory stimuli traced to the central …
Genetic coupling of mate recognition systems in the genomic era
The concept of “genetic coupling” in mate recognition systems arose in the 1960s as a
potential mechanism to maintain coordination between signals and receivers during …
potential mechanism to maintain coordination between signals and receivers during …
iRegulon: from a gene list to a gene regulatory network using large motif and track collections
Identifying master regulators of biological processes and map** their downstream gene
networks are key challenges in systems biology. We developed a computational method …
networks are key challenges in systems biology. We developed a computational method …
Genetics on the Fly: A Primer on the Drosophila Model System
Fruit flies of the genus Drosophila have been an attractive and effective genetic model
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …
A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown
Triglycerides are the major form of stored fat in all animals. One important determinant of
whole-body fat storage is whether an animal is male or female. Here, we use Drosophila, an …
whole-body fat storage is whether an animal is male or female. Here, we use Drosophila, an …
Neuromolecular responses to social challenge: common mechanisms across mouse, stickleback fish, and honey bee
Certain complex phenotypes appear repeatedly across diverse species due to processes of
evolutionary conservation and convergence. In some contexts like developmental body …
evolutionary conservation and convergence. In some contexts like developmental body …
Sex-and tissue-specific functions of Drosophila doublesex transcription factor target genes
Primary sex-determination" switches" evolve rapidly, but Doublesex (DSX)-related
transcription factors (DMRTs) act downstream of these switches to control sexual …
transcription factors (DMRTs) act downstream of these switches to control sexual …
Sex determination gene transformer regulates the male-female difference in Drosophila fat storage via the adipokinetic hormone pathway
Sex differences in whole-body fat storage exist in many species. For example, Drosophila
females store more fat than males. Yet, the mechanisms underlying this sex difference in fat …
females store more fat than males. Yet, the mechanisms underlying this sex difference in fat …
A modular circuit coordinates the diversification of courtship strategies
Mate recognition systems evolve rapidly to reinforce the reproductive boundaries between
species, but the underlying neural mechanisms remain enigmatic. Here we leveraged the …
species, but the underlying neural mechanisms remain enigmatic. Here we leveraged the …
A sex-specific switch between visual and olfactory inputs underlies adaptive sex differences in behavior
Although males and females largely share the same genome and nervous system, they
differ profoundly in reproductive investments and require distinct behavioral, morphological …
differ profoundly in reproductive investments and require distinct behavioral, morphological …