A wide variety of viruses exploit furin and other proprotein convertases (PCs) of the
constitutive protein secretion pathway in order to regulate their cell entry mechanism and …

Retrovirus morphogenesis entails assembly of Gag proteins and the viral genome on the
host plasma membrane, acquisition of the viral membrane and envelope proteins through …

Summary Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor
reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that …

Electron cryotomography (cryoET), an electron cryomicroscopy (cryoEM) modality, has
changed our understanding of biological function by revealing the native molecular details …

After the onset of the AIDS pandemic, HIV-1 (genus Lentivirus) became the predominant
model for studying retrovirus Env glycoproteins and their role in entry. However, HIV Env is …

Host restriction factor GBP2 suppresses the replication of the ecotropic Moloney murine
leukemia virus (E-MLV) by inhibiting furin protease, which cleaves the viral envelope …

Hypervariable loops of HIV-1 Env protein gp120 are speculated to play roles in the
conformational transition of Env to the receptor binding-induced metastable state. Structural …

Viren sind intrazelluläre Parasiten, die zur Vermehrung auf den Stoffwechsel ihres Wirts
angewiesen sind. Ihr Genom ist in ribonucleic acid (Ribonukleinsäure, RNA) oder …

Inhibitors of human furin may represent the clinical remedy for very aggressive cancer, viral,
and bacterial infections. Most of the currently available inhibitors are weak in terms of …