Antisense technology: an overview and prospectus
ST Crooke, BF Baker, RM Crooke… - Nature reviews Drug …, 2021 - nature.com
Antisense technology is now beginning to deliver on its promise to treat diseases by
targeting RNA. Nine single-stranded antisense oligonucleotide (ASO) drugs representing …
targeting RNA. Nine single-stranded antisense oligonucleotide (ASO) drugs representing …
RNA drugs and RNA targets for small molecules: principles, progress, and challenges
RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
Antisense technology: A review
ST Crooke, XH Liang, BF Baker, RM Crooke - Journal of Biological …, 2021 - ASBMB
Antisense technology is beginning to deliver on the broad promise of the technology. Ten
RNA-targeted drugs including eight single-strand antisense drugs (ASOs) and two double …
RNA-targeted drugs including eight single-strand antisense drugs (ASOs) and two double …
Therapeutic targeting of long non-coding RNAs in cancer
Long non-coding RNAs (lncRNAs) represent a significant population of the human
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …
RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform
CF Bennett, EE Swayze - Annual review of pharmacology and …, 2010 - annualreviews.org
Dramatic advances in understanding of the roles RNA plays in normal health and disease
have greatly expanded over the past 10 years and have made it clear that scientists are only …
have greatly expanded over the past 10 years and have made it clear that scientists are only …
Killing the messenger: short RNAs that silence gene expression
DM Dykxhoorn, CD Novina, PA Sharp - Nature reviews Molecular cell …, 2003 - nature.com
Short interfering RNAs can be used to silence gene expression in a sequence-specific
manner in a process that is known as RNA interference. The application of RNA interference …
manner in a process that is known as RNA interference. The application of RNA interference …
Precision RNA base editing with engineered and endogenous effectors
LS Pfeiffer, T Stafforst - Nature Biotechnology, 2023 - nature.com
RNA base editing refers to the rewriting of genetic information within an intact RNA molecule
and serves various functions, such as evasion of the endogenous immune system and …
and serves various functions, such as evasion of the endogenous immune system and …
siRNAs: applications in functional genomics and potential as therapeutics
Y Dorsett, T Tuschl - Nature reviews Drug discovery, 2004 - nature.com
Molecules that can specifically silence gene expression are powerful research tools. Much
effort has been put into the development of such molecules and has resulted in the creation …
effort has been put into the development of such molecules and has resulted in the creation …
Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides
KA Lennox, MA Behlke - Nucleic acids research, 2016 - academic.oup.com
Thousands of long non-coding RNAs (lncRNAs) have been identified in mammalian cells.
Some have important functions and their dysregulation can contribute to a variety of disease …
Some have important functions and their dysregulation can contribute to a variety of disease …
Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference
In the present study, the relationship between short interfering RNA (siRNA) sequence and
RNA interference (RNAi) effect was extensively analyzed using 62 targets of four exogenous …
RNA interference (RNAi) effect was extensively analyzed using 62 targets of four exogenous …