NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …

Propolis is a natural material that honey bees (Apis mellifera) produce from various
botanical sources. The therapeutic activity of propolis, including antibacterial, antifungal, and …

Phenotypic and functional heterogeneity is one of the most relevant features of cancer cells
within different tumor types and is responsible for treatment failure. Cancer stem cells …

Background and objectives: Cancer stem cells (CSCs) have been implicated in tumor
initiation, recurrence, metastatic spread and poor survival in multiple tumor types, breast …

Rationale: Current therapies for metastatic osseous disease frequently fail to provide a
durable treatment response. To date, there are only limited therapeutic options for metastatic …

NAD+ is an important metabolite in cell homeostasis that acts as an essential cofactor in
oxidation–reduction (redox) reactions in various energy production processes, such as the …

This review is directed to the redox-modulating properties and anticancer effect of vitamin K.
The concept is focused on two aspects:(i) redox-cycle of vitamin K and its effect on the …

Here, we devised a new strategy for eradicating cancer stem cells (CSCs), via a “synthetic-
metabolic” approach, involving two FDA-approved antibiotics and a dietary vitamin …

Abstract Vitamin C (Vit C or Ascorbate) is essential for many fundamental biochemical
processes. Vit C is an essential nutrient with redox functions at normal physiologic …

Here, we developed a new synthetic lethal strategy for further optimizing the eradication of
cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved …