Epigenetics is emerging as the missing link among genetic inheritance, environmental
influences, and body and brain health status. In the brain, specific changes in nucleic acids …

Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer's
Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect …

Background Increasing life expectancy but also healthspan seems inaccessible as of yet but
it may become a reality in the foreseeable future. To extend lifespan, it is essential to unveil …

DNA methyltransferases (DNMTs) are widely expressed in the brain, dictating the
transcriptional activity of genes through various epigenetic mechanisms. Functional …

Background During the lifetime of an organism, every individual encounters many
combinations of diverse changes in the somatic genome, epigenome and microbiome. This …

Objective Cartilage epigenetic changes are strongly associated with human osteoarthritis
(OA). However, the influence of individual environmental OA risk factors on these epigenetic …

Coronary artery disease (CAD) is a common health problem in Iranian population. ATP
binding cassette transporter A1 (ABCA1) plays central role in the efflux of the cholesterol …

A health disparity refers to a higher burden of illness, injury, disability, or mortality
experienced by one group relative to others attributable to multiple factors including …

Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer's
Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect …

Organismal aging is normally associated with a decline in bodily functions and an increase
in various disease-related outcomes. Whether aging itself is a disease or is a process …