The IL-17 family in diseases: from bench to bedside

L Huangfu, R Li, Y Huang, S Wang - Signal transduction and targeted …, 2023 - nature.com
Abstract The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and
recently, all of its related receptors have been discovered. IL-17 was first discovered …

The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

C d'Enfert, AK Kaune, LR Alaban… - FEMS microbiology …, 2021 - academic.oup.com
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

IL-17 receptor–based signaling and implications for disease

X Li, R Bechara, J Zhao, MJ McGeachy… - Nature immunology, 2019 - nature.com
IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes,
including host defense, tissue repair, the pathogenesis of inflammatory disease and the …

[HTML][HTML] The skin commensal yeast Malassezia triggers a type 17 response that coordinates anti-fungal immunity and exacerbates skin inflammation

F Sparber, C De Gregorio, S Steckholzer, FM Ferreira… - Cell host & …, 2019 - cell.com
Commensal fungi of the mammalian skin, such as those of the genus Malassezia, are
associated with atopic dermatitis and other common inflammatory skin disorders …

Immunity to fungi in the lung

LJ Heung, DL Wiesner, K Wang, A Rivera… - Seminars in immunology, 2023 - Elsevier
The respiratory tree maintains sterilizing immunity against human fungal pathogens.
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …

The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract

O Perdijk, R Azzoni, BJ Marsland - Physiological Reviews, 2024 - journals.physiology.org
The last decade of microbiome research has highlighted its fundamental role in systemic
immune and metabolic homeostasis. The microbiome plays a prominent role during …

Epithelial cells: liaisons of immunity

SB Larsen, CJ Cowley, E Fuchs - Current opinion in immunology, 2020 - Elsevier
Highlights•Epithelial cells sense their microenvironment via an arsenal of pattern recognition
receptors that inform downstream responses.•Microbial species tune epithelial-immune cell …

The Host Microbiota Contributes to Early Protection Against Lung Colonization by Mycobacterium tuberculosis

A Dumas, D Corral, A Colom, F Levillain… - Frontiers in …, 2018 - frontiersin.org
Tuberculosis (TB), caused by the airborne bacterial pathogen Mycobacterium tuberculosis,
remains a major source of morbidity and mortality worldwide. So far, the study of host …

Molecular mechanisms that govern infection and antifungal resistance in Mucorales

C Lax, FE Nicolás, E Navarro… - … and Molecular Biology …, 2024 - journals.asm.org
SUMMARY The World Health Organization has established a fungal priority pathogens list
that includes species critical or highly important to human health. Among them is the order …

The role of neutrophils in host defense against invasive fungal infections

JV Desai, MS Lionakis - Current clinical microbiology reports, 2018 - Springer
Abstract Purpose of Review Invasive fungal infections caused by the commensal yeast
Candida and the ubiquitous, inhaled mold Aspergillus have emerged as major causes of …