Learning without neurons in physical systems

M Stern, A Murugan - Annual Review of Condensed Matter …, 2023 - annualreviews.org
Learning is traditionally studied in biological or computational systems. The power of
learning frameworks in solving hard inverse problems provides an appealing case for the …

Pathways to cellular supremacy in biocomputing

L Grozinger, M Amos, TE Gorochowski… - Nature …, 2019 - nature.com
Synthetic biology uses living cells as the substrate for performing human-defined
computations. Many current implementations of cellular computing are based on the …

Programmable chemical controllers made from DNA

YJ Chen, N Dalchau, N Srinivas, A Phillips… - Nature …, 2013 - nature.com
Biological organisms use complex molecular networks to navigate their environment and
regulate their internal state. The development of synthetic systems with similar capabilities …

DNA as a universal substrate for chemical kinetics

D Soloveichik, G Seelig, E Winfree - … of the National Academy of Sciences, 2010 - pnas.org
Molecular programming aims to systematically engineer molecular and chemical systems of
autonomous function and ever-increasing complexity. A key goal is to develop embedded …

Nonequilibrium thermodynamics of chemical reaction networks: Wisdom from stochastic thermodynamics

R Rao, M Esposito - Physical Review X, 2016 - APS
We build a rigorous nonequilibrium thermodynamic description for open chemical reaction
networks of elementary reactions. Their dynamics is described by deterministic rate …

Real-time signal processing via chemical reactions for a microfluidic molecular communication system

V Walter, D Bi, A Salehi-Reyhani, Y Deng - Nature Communications, 2023 - nature.com
Signal processing over the molecular domain is critical for analysing, modifying, and
synthesising chemical signals in molecular communication systems. However, the lack of …

The stochastic thermodynamics of computation

DH Wolpert - Journal of Physics A: Mathematical and Theoretical, 2019 - iopscience.iop.org
One of the central concerns of computer science is how the resources needed to perform a
given computation depend on that computation. Moreover, one of the major resource …

An RNA-based theory of natural universal computation

H Akhlaghpour - Journal of Theoretical Biology, 2022 - Elsevier
Life is confronted with computation problems in a variety of domains including animal
behavior, single-cell behavior, and embryonic development. Yet we currently do not know of …

Analog computation by DNA strand displacement circuits

T Song, S Garg, R Mokhtar, H Bui, J Reif - ACS synthetic biology, 2016 - ACS Publications
DNA circuits have been widely used to develop biological computing devices because of
their high programmability and versatility. Here, we propose an architecture for the …

Deterministic function computation with chemical reaction networks

HL Chen, D Doty, D Soloveichik - Natural computing, 2014 - Springer
Chemical reaction networks (CRNs) formally model chemistry in a well-mixed solution.
CRNs are widely used to describe information processing occurring in natural cellular …