[HTML][HTML] Biological role and therapeutic potential of IDH mutations in cancer
Hotspot mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2
(IDH2) occur in a variety of myeloid malignancies and solid tumors. Mutant IDH proteins …
(IDH2) occur in a variety of myeloid malignancies and solid tumors. Mutant IDH proteins …
Isocitrate dehydrogenase mutations in gliomas
Over the last decade, extraordinary progress has been made in elucidating the underlying
genetic causes of gliomas. In 2008, our understanding of glioma genetics was …
genetic causes of gliomas. In 2008, our understanding of glioma genetics was …
Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression
Neutrophils are a vital component of immune protection, yet in cancer they may promote
tumour progression, partly by generating reactive oxygen species (ROS) that disrupts …
tumour progression, partly by generating reactive oxygen species (ROS) that disrupts …
A human kidney and liver organoid‐based multi‐organ‐on‐a‐chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell‐derived …
Mesenchymal stromal cell (MSC)‐derived small extracellular vesicles (sEVs) show
therapeutic potential in multiple disease models, including kidney injury. Clinical translation …
therapeutic potential in multiple disease models, including kidney injury. Clinical translation …
Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury
Endothelial nitric oxide synthase (eNOS) is protective against kidney injury, but the
molecular mechanisms of this protection are poorly understood,. Nitric oxide-based cellular …
molecular mechanisms of this protection are poorly understood,. Nitric oxide-based cellular …
The significance of NAD+ metabolites and nicotinamide N-methyltransferase in chronic kidney disease
R Takahashi, T Kanda, M Komatsu, T Itoh… - Scientific reports, 2022 - nature.com
Dysregulation of nicotinamide adenine dinucleotide (NAD+) metabolism contributes to the
initiation and progression of age-associated diseases, including chronic kidney disease …
initiation and progression of age-associated diseases, including chronic kidney disease …
Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma?
NK Kloosterhof, LBC Bralten, HJ Dubbink… - The lancet …, 2011 - thelancet.com
The discovery of somatic mutations in the gene encoding isocitrate dehydrogenase-1 (IDH1)
in glioblastomas was remarkable because the enzyme was not previously identified with any …
in glioblastomas was remarkable because the enzyme was not previously identified with any …
Reactive oxygen species/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice
J Kim, YM Seok, KJ Jung… - American Journal of …, 2009 - journals.physiology.org
Recently, kidney fibrosis following transplantation has become recognized as a main
contributor of chronic allograft nephropathy. In transplantation, transient ischemia is an …
contributor of chronic allograft nephropathy. In transplantation, transient ischemia is an …
IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma
Isocitrate dehydrogenase (IDH) enzymes have recently become a focal point for research
aimed at understanding the biology of glioma. IDH1 and IDH2 are mutated in 50%–80% of …
aimed at understanding the biology of glioma. IDH1 and IDH2 are mutated in 50%–80% of …
Natural vitamin E α-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1
Background and Purpose—α-Tocotrienol (TCT) represents the most potent neuroprotective
form of natural vitamin E that is Generally Recognized As Safe certified by the US Food and …
form of natural vitamin E that is Generally Recognized As Safe certified by the US Food and …