The genetic bases of neuropsychiatric disorders are beginning to yield to scientific inquiry.
Genome-wide studies of copy number variation (CNV) have given rise to a new …

Congenital heart disease (CHD) affects nearly 1% of the population. It is a complex disease,
which may be caused by multiple genetic and environmental factors. Studies in human …

Abstract The Holocene (beginning around 12,000 years ago) encompassed some of the
most significant changes in human evolution, with far-reaching consequences for the …

Children with congenital heart disease (CHD) are at increased risk of neurodevelopmental
disorders (NDDs) and psychiatric conditions. These include cognitive, adaptive, motor …

Several lines of evidence suggest that proliferation and differentiation in neural stem cells
(NSCs) are a major convergence point of neurodevelopmental disorders (NDDs). Most …

Common neurodevelopmental disorders (including autism, speech and language delay,
schizophrenia, epilepsy and intellectual disability) have complex aetiology, which is …

Autism spectrum disorders (ASD) encompass a group of neurodevelopmental diseases that
demonstrate strong heritability, however, the inheritance is not simple and many genes have …

Copy number variants (CNVs) at chromosome 16p13. 11 have been associated with a
range of neurodevelopmental disorders including autism, ADHD, intellectual disability and …

Congenital heart disease (CHD) is the most common congenital malformation, with
evidence of a strong genetic component. We analyzed data from 223 consecutively …

Background—Human genomes harbor copy number variants (CNVs), which are regions of
DNA gains or losses. Although pathogenic CNVs are associated with congenital heart …