The molecular principles of gene regulation by Polycomb repressive complexes
NP Blackledge, RJ Klose - Nature reviews Molecular cell biology, 2021 - nature.com
Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
The roles of Polycomb repressive complexes in mammalian development and cancer
More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
Abstract Canonical (H3. 1/H3. 2) and noncanonical (H3. 3) histone 3 K27M-mutant gliomas
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation
Histone-modifying enzymes are implicated in the control of diverse DNA-templated
processes including gene expression. Here, we outline historical and current thinking …
processes including gene expression. Here, we outline historical and current thinking …
Context-specific Polycomb mechanisms in development
Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …
The interplay between DNA and histone methylation: molecular mechanisms and disease implications
Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …
chromatin modification that critically contributes to the regulation of genome integrity …
[HTML][HTML] ONC201 and imipridones: Anti-cancer compounds with clinical efficacy
ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-
inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G …
inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G …
Polycomb gene silencing mechanisms: PRC2 chromatin targeting, H3K27me3'readout', and phase separation-based compaction
Modulation of chromatin structure and/or modification by Polycomb repressive complexes
(PRCs) provides an important means to partition the genome into functionally distinct …
(PRCs) provides an important means to partition the genome into functionally distinct …
Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours
The spectrum of tumours arising in childhood is fundamentally different from that seen in
adults, and they are known to be divergent from adult malignancies in terms of cellular …
adults, and they are known to be divergent from adult malignancies in terms of cellular …
[HTML][HTML] BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation
BAP1 is mutated or deleted in many cancer types, including mesothelioma, uveal
melanoma, and cholangiocarcinoma. It is the catalytic subunit of the PR-DUB complex …
melanoma, and cholangiocarcinoma. It is the catalytic subunit of the PR-DUB complex …