Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

Gut microbiome–brain alliance: a landscape view into mental and gastrointestinal health and disorders

JM Sasso, RM Ammar, R Tenchov… - ACS Chemical …, 2023 - ACS Publications
Gut microbiota includes a vast collection of microorganisms residing within the
gastrointestinal tract. It is broadly recognized that the gut and brain are in constant …

LNCcation: lncRNA localization and function

MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

Expanded encyclopaedias of DNA elements in the human and mouse genomes

JE Moore, MJ Purcaro, HE Pratt, CB Epstein… - Nature, 2020 - nature.com
The human and mouse genomes contain instructions that specify RNAs and proteins and
govern the timing, magnitude, and cellular context of their production. To better delineate …

Single-cell nascent RNA sequencing unveils coordinated global transcription

DB Mahat, ND Tippens, JD Martin-Rufino, SK Waterton… - Nature, 2024 - nature.com
Transcription is the primary regulatory step in gene expression. Divergent transcription
initiation from promoters and enhancers produces stable RNAs from genes and unstable …

Identification of non-coding silencer elements and their regulation of gene expression

B Pang, JH van Weerd, FL Hamoen… - … Reviews Molecular Cell …, 2023 - nature.com
Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …

GENCODE reference annotation for the human and mouse genomes

A Frankish, M Diekhans, AM Ferreira… - Nucleic acids …, 2019 - academic.oup.com
The accurate identification and description of the genes in the human and mouse genomes
is a fundamental requirement for high quality analysis of data informing both genome …

[HTML][HTML] Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

FK Satterstrom, JA Kosmicki, J Wang, MS Breen… - Cell, 2020 - cell.com
We present the largest exome sequencing study of autism spectrum disorder (ASD) to date
(n= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

P Wu, Y Mo, M Peng, T Tang, Y Zhong, X Deng… - Molecular cancer, 2020 - Springer
Non-coding RNAs do not encode proteins and regulate various oncological processes. They
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

MJ Gandal, P Zhang, E Hadjimichael, RL Walker… - Science, 2018 - science.org
INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders,
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …