A major challenge in current biology is to understand the genetic basis of variation for
quantitative traits. We review the principles of quantitative trait locus map** and …

Over the last 20 years, studies of Caenorhabditis elegans natural diversity have
demonstrated the power of quantitative genetic approaches to reveal the evolutionary …

Pseudouridine is the most abundant RNA modification, yet except for a few well-studied
cases, little is known about the modified positions and their function (s). Here, we develop Ψ …

CRISPR-Cas genome engineering in yeast has relied on preparation of complex expression
plasmids for multiplexed gene knockouts and point mutations. Here we show that co …

The question of how genetic variation in a population influences phenotypic variation and
evolution is of major importance in modern biology. Yet much is still unknown about the …

With global warming and climate change, breeding crop plants tolerant to high-temperature
stress is of immense significance. tRNA 2-thiolation is a highly conserved form of tRNA …

One approach to understanding the genetic basis of traits is to study their pattern of
inheritance among offspring of phenotypically different parents. Previously, such analysis …

Bioethanol is a biofuel produced mainly from the fermentation of carbohydrates derived from
agricultural feedstocks by the yeast Saccharomyces cerevisiae. One of the most widely …

Epistasis can markedly affect evolutionary trajectories. In recent decades, protein-level
fitness landscapes have revealed extensive idiosyncratic epistasis among specific …

Thermotolerance is a polygenic trait that contributes to cell survival and growth under
unusually high temperatures. Although some genes associated with high-temperature …