Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or
diversification of novel molecular entities with improved physicochemical or biological …

The progress of drug discovery and development is paced by milestones reached in organic
synthesis. In the last decade, the advent of late-stage functionalization (LSF) reactions has …

An electrochemical asymmetric coupling of secondary acyclic amines with ketones via a
Shono-type oxidation has been described, affording the corresponding amino acid …

Herein, an electrochemically driven NiH‐catalyzed reductive coupling of alkyl halides and
alkyl alkenes for the construction of Csp3− Csp3 bonds is firstly reported. Notably, alkyl …

Although electrochemical strategies for small-molecule synthesis are flourishing, this
technology has yet to be fully exploited for the mild and chemoselective modification of …

Abstract Oxidative C (sp 3)–H bond functionalization is a powerful tool in organic synthesis,
but the stoichiometric oxidants required for bond formation raise environmental concerns …

We report a general protocol for the convergent synthesis of 1, 4-dicarbonyl Z-alkenes form
alkynes using α-diazo sulfonium triflate and water. The C═ O, C═ C, and C–H bonds are …

The ubiquity of sulfur‐containing molecules in biologically active natural products and
pharmaceuticals has long attracted synthetic chemists to develop efficient strategies towards …

摘要 有机电化学合成已成为一种实用, 环境友好的合成方法, 广泛应用于氧化,
还原以及氧化还原中性反应. 通过精准调控电流或者电位可在温和反应条件下实现一些具有挑战 …

Transition-metal-catalyzed cross-coupling reactions of thioesters by selective acyl C (O)–S
cleavage have emerged as a powerful platform for the preparation of complex molecules …