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Primary open-angle glaucoma
RN Weinreb, CKS Leung, JG Crowston… - Nature reviews Disease …, 2016 - nature.com
Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …
The molecular basis of retinal ganglion cell death in glaucoma
M Almasieh, AM Wilson, B Morquette… - Progress in retinal and …, 2012 - Elsevier
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …
results in visual field loss and irreversible blindness. A crucial element in the …
Pan-retinal ganglion cell markers in mice, rats, and rhesus macaques
Univocal identification of retinal ganglion cells (RGCs) is an essential prerequisite for
studying their degeneration and neuroprotection. Before the advent of phenotypic markers …
studying their degeneration and neuroprotection. Before the advent of phenotypic markers …
IOP and glaucoma damage: The essential role of optic nerve head and retinal mechanosensors
There are many unanswered questions on the relation of intraocular pressure to glaucoma
development and progression. IOP itself cannot be distilled to a single, unifying value …
development and progression. IOP itself cannot be distilled to a single, unifying value …
Critical pathogenic events underlying progression of neurodegeneration in glaucoma
DJ Calkins - Progress in retinal and eye research, 2012 - Elsevier
Glaucoma is a common optic neuropathy with a complex etiology often linked to sensitivity to
intraocular pressure. Though the precise mechanisms that mediate or transduce this …
intraocular pressure. Though the precise mechanisms that mediate or transduce this …
Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy
Glaucoma is a complex neurodegenerative disorder that is expected to affect 80 million
people by the end of this decade. Retinal ganglion cells (RGCs) are the most affected cell …
people by the end of this decade. Retinal ganglion cells (RGCs) are the most affected cell …
[HTML][HTML] Neuroinflammation in primary open-angle glaucoma
S Vernazza, S Tirendi, AM Bassi, CE Traverso… - Journal of clinical …, 2020 - mdpi.com
Primary open-angle glaucoma (POAG) is the second leading cause of irreversible blindness
worldwide. Increasing evidence suggests oxidative damage and immune response defects …
worldwide. Increasing evidence suggests oxidative damage and immune response defects …
[HTML][HTML] Signalling pathways and cell death mechanisms in glaucoma: Insights into the molecular pathophysiology
Glaucoma is a complex multifactorial eye disease manifesting in retinal ganglion cell (RGC)
death and optic nerve degeneration, ultimately causing irreversible vision loss. Research in …
death and optic nerve degeneration, ultimately causing irreversible vision loss. Research in …
[HTML][HTML] Understanding glaucomatous damage: anatomical and functional data from ocular hypertensive rodent retinas
Glaucoma, the second most common cause of blindness, is characterized by a progressive
loss of retinal ganglion cells and their axons, with a concomitant loss of the visual field …
loss of retinal ganglion cells and their axons, with a concomitant loss of the visual field …
Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma
Optic nerve head (ONH) astrocytes have been proposed to play both protective and
deleterious roles in glaucoma. We now show that, within the postlaminar ONH myelination …
deleterious roles in glaucoma. We now show that, within the postlaminar ONH myelination …