Primary open-angle glaucoma

RN Weinreb, CKS Leung, JG Crowston… - Nature reviews Disease …, 2016 - nature.com
Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …

The molecular basis of retinal ganglion cell death in glaucoma

M Almasieh, AM Wilson, B Morquette… - Progress in retinal and …, 2012 - Elsevier
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Pan-retinal ganglion cell markers in mice, rats, and rhesus macaques

FM Nadal-Nicolás, C Galindo-Romero… - Zoological …, 2023 - pmc.ncbi.nlm.nih.gov
Univocal identification of retinal ganglion cells (RGCs) is an essential prerequisite for
studying their degeneration and neuroprotection. Before the advent of phenotypic markers …

IOP and glaucoma damage: The essential role of optic nerve head and retinal mechanosensors

I Pitha, L Du, TD Nguyen, H Quigley - Progress in retinal and eye research, 2024 - Elsevier
There are many unanswered questions on the relation of intraocular pressure to glaucoma
development and progression. IOP itself cannot be distilled to a single, unifying value …

Critical pathogenic events underlying progression of neurodegeneration in glaucoma

DJ Calkins - Progress in retinal and eye research, 2012 - Elsevier
Glaucoma is a common optic neuropathy with a complex etiology often linked to sensitivity to
intraocular pressure. Though the precise mechanisms that mediate or transduce this …

Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy

RW Nickells, GR Howell, I Soto… - Annual review of …, 2012 - annualreviews.org
Glaucoma is a complex neurodegenerative disorder that is expected to affect 80 million
people by the end of this decade. Retinal ganglion cells (RGCs) are the most affected cell …

[HTML][HTML] Neuroinflammation in primary open-angle glaucoma

S Vernazza, S Tirendi, AM Bassi, CE Traverso… - Journal of clinical …, 2020 - mdpi.com
Primary open-angle glaucoma (POAG) is the second leading cause of irreversible blindness
worldwide. Increasing evidence suggests oxidative damage and immune response defects …

[HTML][HTML] Signalling pathways and cell death mechanisms in glaucoma: Insights into the molecular pathophysiology

D Basavarajappa, C Galindo-Romero, V Gupta… - Molecular Aspects of …, 2023 - Elsevier
Glaucoma is a complex multifactorial eye disease manifesting in retinal ganglion cell (RGC)
death and optic nerve degeneration, ultimately causing irreversible vision loss. Research in …

[HTML][HTML] Understanding glaucomatous damage: anatomical and functional data from ocular hypertensive rodent retinas

M Vidal-Sanz, M Salinas-Navarro… - Progress in retinal and …, 2012 - Elsevier
Glaucoma, the second most common cause of blindness, is characterized by a progressive
loss of retinal ganglion cells and their axons, with a concomitant loss of the visual field …

Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma

JV Nguyen, I Soto, KY Kim, EA Bushong… - Proceedings of the …, 2011 - pnas.org
Optic nerve head (ONH) astrocytes have been proposed to play both protective and
deleterious roles in glaucoma. We now show that, within the postlaminar ONH myelination …