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The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions
Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …
Microglia in the neuroinflammatory pathogenesis of Alzheimer's disease and related therapeutic targets
Y Cai, J Liu, B Wang, M Sun, H Yang - Frontiers in immunology, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide,
characterized by progressive neuron degeneration or loss due to excessive accumulation of …
characterized by progressive neuron degeneration or loss due to excessive accumulation of …
Curcumin‐piperine co‐supplementation and human health: A comprehensive review of preclinical and clinical studies
Curcumin is extracted from the rhizomes Curcuma longa L. It is known for its anti‐
inflammatory and anti‐oxidant activities. Despite its safety and potential for use against …
inflammatory and anti‐oxidant activities. Despite its safety and potential for use against …
[HTML][HTML] Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities
VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …
The anti-inflammatory and immunomodulatory activities of natural products to control autoimmune inflammation
Inflammation is an integral part of autoimmune diseases, which are caused by dysregulation
of the immune system. This dysregulation involves an imbalance between pro-inflammatory …
of the immune system. This dysregulation involves an imbalance between pro-inflammatory …
[HTML][HTML] Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential
YS Fu, TH Chen, L Weng, L Huang, D Lai… - Biomedicine & …, 2021 - Elsevier
Curcumin, isolated from Curcuma longa L., is a fat-soluble natural compound that can be
obtained from ginger plant tuber roots, which accumulative evidences have demonstrated …
obtained from ginger plant tuber roots, which accumulative evidences have demonstrated …
[HTML][HTML] Oral curcumin with piperine as adjuvant therapy for the treatment of COVID-19: A randomized clinical trial
KS Pawar, RN Mastud, SK Pawar, SS Pawar… - Frontiers in …, 2021 - frontiersin.org
Background: Coronavirus disease-2019 (COVID-19) has a wide range of pathophysiological
effects. Curcumin, an active constituent of Curcuma longa (turmeric), has several properties …
effects. Curcumin, an active constituent of Curcuma longa (turmeric), has several properties …
Curcumin: an inflammasome silencer
Curcumin is the major bioactive polyphenolic ingredient of turmeric. Increasing evidence
indicates that the health benefits of curcumin are mediated through its anti-inflammatory and …
indicates that the health benefits of curcumin are mediated through its anti-inflammatory and …
Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects of Curcuma longa and curcumin, an updated and comprehensive …
Curcuma longa (C. longa) or turmeric is a plant with a long history of use in traditional
medicine, especially for treating inflammatory conditions C. longa and its main constituent …
medicine, especially for treating inflammatory conditions C. longa and its main constituent …
The multifaceted role of curcumin in advanced nanocurcumin form in the treatment and management of chronic disorders
Curcumin is the primary polyphenol in turmeric's curcuminoid class. It has a wide range of
therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic …
therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic …