Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Extracellular vesicles are released by the majority of cell types and circulate in body fluids.
They function as a long-distance cell-to-cell communication mechanism that modulates the …

Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific
immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such …

Despite recent advances in the management of chronic kidney disease (CKD), morbidity
and mortality rates in these patients remain high. While pressure-mediated injury is a well …

Diabetic kidney disease (DKD) is the major cause of end-stage kidney disease. However,
only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD …

Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

Obesity and hyperlipidemia are the most prevalent independent risk factors of chronic
kidney disease (CKD), suggesting that lipid accumulation in the renal parenchyma is …

Recent clinical studies indicate a strong link between AKI and progression of CKD. The
increasing prevalence of AKI must compel the nephrology community to consider the long …

Abstract Sodium glucose cotransporter 2 (SGLT2) inhibitors are beneficial in halting diabetic
kidney disease; however, the complete mechanisms have not yet been elucidated. The …

Ischemia-reperfusion injury (IRI) during renal transplantation often initiates non-specific
inflammatory responses that can result in the loss of kidney graft viability. However, the long …