In the last decade, the generation of cardiac disease models based on human-induced
pluripotent stem cells (hiPSCs) has become of common use, providing new opportunities to …

Aims Sarcomeric gene mutations frequently underlie hypertrophic cardiomyopathy (HCM), a
prevalent and complex condition leading to left ventricle thickening and heart dysfunction …

Substantial experimental and epidemiological data have highlighted the interplay between
nutritional and genetic factors in the development of congenital heart defects. Retinoic acid …

Rationale: Activated fibroblasts are the major cell type that secretes excessive extracellular
matrix in response to injury, contributing to pathological fibrosis and leading to organ failure …

Recent studies using human pluripotent stem cells (hPSCs) have developed protocols to
induce kidney-lineage cells and reconstruct kidney organoids. However, the separate …

Epicardial formation is necessary for normal myocardial morphogenesis. Here, we show that
differentiating hiPSC-derived lateral plate mesoderm with BMP4, RA and VEGF (BVR) can …

Ischemic heart failure is due to irreversible loss of cardiomyocytes. Preclinical studies
showed that human pluripotent stem cell (hPSC)-derived cardiomyocytes could …

The epicardium, previously viewed as a passive outer layer around the heart, is now
recognized as an essential component in development, regeneration, and repair. In this …

During heart development, epicardial cells residing within the outer layer undergo epithelial-
mesenchymal transition (EMT) and migrate into the underlying myocardium to support organ …

The neural crest (NC) is a transient multipotent cell population present during embryonic
development. The NC can give rise to multiple cell types and is involved in a number of …