Kidney stone disease causes significant morbidity and increases health care utilization. In
this work, we decipher the cellular and molecular niche of the human renal papilla in …

The ability to localize hundreds of macromolecules to discrete locations, structures and cell
types in a tissue is a powerful approach to understand the cellular and spatial organization …

Pig-to-human xenotransplantation is rapidly approaching the clinical arena; however, it is
unclear which immunomodulatory regimens will effectively control human immune …

In this paper we describe a set of 3D microscopy volumes we have partially manually
annotated. We describe the volumes annotated and the tools and processes we use to …

The long-term effects of a single episode of acute kidney injury (AKI) induced by bilateral
ischemia-reperfusion injury (BIRI) on kidney lymphatic dynamics are not known. The …

Recovery from acute kidney injury can vary widely in patients and in animal models.
Immunofluorescence staining can provide spatial information about heterogeneous injury …

Endoscopic and biopsy findings have identified two distinct phenotypes among individuals
with calcium oxalate (CaOx) kidney stones. The first type has normal renal papillae but …

The kidney is a complex organ and a key regulator of homeostasis. It comprises various
functional units (nephrons, vasculature, and interstitium) that are organized spatially, so that …

Advances in cellular and molecular interrogation of kidney tissue have ushered a new era of
understanding the pathogenesis of kidney disease and potentially identifying molecular …

Kidney stone disease causes significant morbidity and increases health care utilization. The
pathogenesis of stone disease is not completely understood, due in part to the poor …